IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms4699.html
   My bibliography  Save this article

Transmission from the dominant input shapes the stereotypic ratio of photoreceptor inputs onto horizontal cells

Author

Listed:
  • Takeshi Yoshimatsu

    (University of Washington)

  • Philip R. Williams

    (University of Washington
    Institute of Neuronal Cell Biology, Technische Universität München)

  • Florence D. D’Orazi

    (University of Washington)

  • Sachihiro C. Suzuki

    (University of Washington)

  • James M. Fadool

    (The Florida State University)

  • W. Ted Allison

    (University of Alberta)

  • Pamela A. Raymond

    (Cellular, and Developmental Biology, University of Michigan)

  • Rachel O. Wong

    (University of Washington)

Abstract

Many neurons receive synapses in stereotypic proportions from converging but functionally distinct afferents. However, developmental mechanisms regulating synaptic convergence are not well understood. Here we describe a heterotypic mechanism by which one afferent controls synaptogenesis of another afferent, but not vice versa. Like other CNS circuits, zebrafish retinal H3 horizontal cells (HC) undergo an initial period of remodelling, establishing synapses with ultraviolet and blue cones while eliminating red and green cone contacts. As development progresses, the HCs selectively synapse with ultraviolet cones to generate a 5:1 ultraviolet-to-blue cone synapse ratio. Blue cone synaptogenesis increases in mutants lacking ultraviolet cones, and when transmitter release or visual stimulation of ultraviolet cones is perturbed. Connectivity is unaltered when blue cone transmission is suppressed. Moreover, there is no cell-autonomous regulation of cone synaptogenesis by neurotransmission. Thus, biased connectivity in this circuit is established by an unusual activity-dependent, unidirectional control of synaptogenesis exerted by the dominant input.

Suggested Citation

  • Takeshi Yoshimatsu & Philip R. Williams & Florence D. D’Orazi & Sachihiro C. Suzuki & James M. Fadool & W. Ted Allison & Pamela A. Raymond & Rachel O. Wong, 2014. "Transmission from the dominant input shapes the stereotypic ratio of photoreceptor inputs onto horizontal cells," Nature Communications, Nature, vol. 5(1), pages 1-12, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4699
    DOI: 10.1038/ncomms4699
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms4699
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms4699?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4699. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.