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Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients

Author

Listed:
  • Fengming Huang

    (State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University)

  • Jing Guo

    (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases)

  • Zhen Zou

    (State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University)

  • Jun Liu

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention)

  • Bin Cao

    (Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University)

  • Shuyang Zhang

    (Center for Translational Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences
    Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences)

  • Hui Li

    (Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University)

  • Wei Wang

    (State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University)

  • Miaomiao Sheng

    (State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University)

  • Song Liu

    (State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University)

  • Jingcao Pan

    (Hangzhou Center for Disease Control and Prevention)

  • Changjun Bao

    (Jiangsu Provincial Center for Disease Control and Prevention)

  • Mei Zeng

    (Children’s Hospital Affiliated with Fudan University)

  • Haixia Xiao

    (Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial, Biotechnology, Chinese Academy of Sciences)

  • Guirong Qian

    (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases)

  • Xinjun Hu

    (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases)

  • Yuanting Chen

    (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases)

  • Yu Chen

    (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases)

  • Yan Zhao

    (State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University)

  • Qiang Liu

    (State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University)

  • Huandi Zhou

    (State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University)

  • Jindong Zhu

    (State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University)

  • Hainv Gao

    (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases)

  • Shigui Yang

    (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases)

  • Xiaoli Liu

    (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases)

  • Shufa Zheng

    (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases)

  • Jiezuan Yang

    (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases)

  • Hongyan Diao

    (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases)

  • Hongcui Cao

    (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases)

  • Ying Wu

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Min Zhao

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Shuguang Tan

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Dan Guo

    (Center for Translational Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences
    Clinical Biobank, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences)

  • Xiliang Zhao

    (Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences)

  • Yicong Ye

    (Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences)

  • Wei Wu

    (Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences)

  • Yingchun Xu

    (Center for Translational Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences
    Clinical Biobank, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences)

  • Josef M. Penninger

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Dangsheng Li

    (Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • George F. Gao

    (Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
    Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC))

  • Chengyu Jiang

    (State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University
    Center for Translational Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences)

  • Lanjuan Li

    (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases)

Abstract

A novel influenza A (H7N9) virus of avian origin emerged in eastern China in the spring of 2013. This virus causes severe disease in humans, including acute and often lethal respiratory failure. As of January 2014, 275 cases of H7N9-infected patients had been reported, highlighting the urgency of identifying biomarkers for predicting disease severity and fatal outcomes. Here, we show that plasma levels of angiotensin II, a major regulatory peptide of the renin–angiotensin system, are markedly elevated in H7N9 patients and are associated with disease progression. Moreover, the sustained high levels of angiotensin II in these patients are strongly correlated with mortality. The predictive value of angiotensin II is higher than that of C-reactive protein and some clinical parameters such as the PaO2/FiO2 ratio (partial pressure of arterial oxygen to the fraction of inspired oxygen). Our findings indicate that angiotensin II is a biomarker for lethality in flu infections.

Suggested Citation

  • Fengming Huang & Jing Guo & Zhen Zou & Jun Liu & Bin Cao & Shuyang Zhang & Hui Li & Wei Wang & Miaomiao Sheng & Song Liu & Jingcao Pan & Changjun Bao & Mei Zeng & Haixia Xiao & Guirong Qian & Xinjun H, 2014. "Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients," Nature Communications, Nature, vol. 5(1), pages 1-7, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4595
    DOI: 10.1038/ncomms4595
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