IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms4578.html
   My bibliography  Save this article

Cell wall precursors are required to organize the chlamydial division septum

Author

Listed:
  • Nicolas Jacquier

    (Institute of Microbiology, University Hospital Center and University of Lausanne)

  • Antonio Frandi

    (Institute of Genetics & Genomics in Geneva (iGE3), Faculty of Medicine / CMU, University of Geneva)

  • Trestan Pillonel

    (Institute of Microbiology, University Hospital Center and University of Lausanne)

  • Patrick H. Viollier

    (Institute of Genetics & Genomics in Geneva (iGE3), Faculty of Medicine / CMU, University of Geneva)

  • Gilbert Greub

    (Institute of Microbiology, University Hospital Center and University of Lausanne)

Abstract

Members of the Chlamydiales order are major bacterial pathogens that divide at mid-cell, without a sequence homologue of the FtsZ cytokinetic tubulin and without a classical peptidoglycan cell wall. Moreover, the spatiotemporal mechanisms directing constriction in Chlamydia are not known. Here we show that the MreB actin homologue and its conserved regulator RodZ localize to the division furrow in Waddlia chondrophila, a member of the Chlamydiales order implicated in human miscarriage. RodZ is recruited to the septal site earlier than MreB and in a manner that depends on biosynthesis of the peptidoglycan precursor lipid II by the MurA enzyme. By contrast, crosslinking of lipid II peptides by the Pbp3 transpeptidase disperses RodZ from the septum. Altogether, these findings provide a cytological framework for understanding chlamydial cytokinesis driven by septal cell wall synthesis.

Suggested Citation

  • Nicolas Jacquier & Antonio Frandi & Trestan Pillonel & Patrick H. Viollier & Gilbert Greub, 2014. "Cell wall precursors are required to organize the chlamydial division septum," Nature Communications, Nature, vol. 5(1), pages 1-11, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4578
    DOI: 10.1038/ncomms4578
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms4578
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms4578?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4578. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.