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FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability

Author

Listed:
  • Beatriz León

    (University of Alabama at Birmingham)

  • John E. Bradley

    (University of Alabama at Birmingham)

  • Frances E. Lund

    (University of Alabama at Birmingham)

  • Troy D. Randall

    (University of Alabama at Birmingham)

  • André Ballesteros-Tato

    (University of Alabama at Birmingham)

Abstract

Here, we test the role of FoxP3+ regulatory T cells (Tregs) in controlling T follicular helper (Tfh) and germinal centre (GC) B-cell responses to influenza. In contrast to the idea that Tregs suppress T-cell responses, we find that Treg depletion severely reduces the Tfh cell response to influenza virus. Furthermore, Treg depletion prevents the accumulation of influenza-specific GCs. These effects are not due to alterations in TGFβ availability or a precursor–progeny relationship between Tregs and Tfh cells, but are instead mediated by increased availability of IL-2, which suppresses the differentiation of Tfh cells and as a consequence, compromises the GC B response. Thus, Tregs promote influenza-specific GC responses by preventing excessive IL-2 signalling, which suppresses Tfh cell differentiation.

Suggested Citation

  • Beatriz León & John E. Bradley & Frances E. Lund & Troy D. Randall & André Ballesteros-Tato, 2014. "FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability," Nature Communications, Nature, vol. 5(1), pages 1-10, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4495
    DOI: 10.1038/ncomms4495
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