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ATM specifically mediates repair of double-strand breaks with blocked DNA ends

Author

Listed:
  • Alejandro Álvarez-Quilón

    (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER))

  • Almudena Serrano-Benítez

    (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER))

  • Jenna Ariel Lieberman

    (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER))

  • Cristina Quintero

    (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER))

  • Daniel Sánchez-Gutiérrez

    (Instituto Biomedicina Sevilla (IBiS))

  • Luis M. Escudero

    (Instituto Biomedicina Sevilla (IBiS))

  • Felipe Cortés-Ledesma

    (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER))

Abstract

Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator of signalling following DNA double-strand breaks (DSBs) has been dissected in extraordinary detail, but the impact of this process on DSB repair still remains controversial. Here we develop novel genetic and molecular tools to modify the structure of DSB ends and demonstrate that ATM is indeed required for efficient and accurate DSB repair, preventing cell death and genome instability, but exclusively when the ends are irreversibly blocked. We therefore identify the nature of ATM involvement in DSB repair, presenting blocked DNA ends as a possible pathogenic trigger of ataxia telangiectasia and related disorders.

Suggested Citation

  • Alejandro Álvarez-Quilón & Almudena Serrano-Benítez & Jenna Ariel Lieberman & Cristina Quintero & Daniel Sánchez-Gutiérrez & Luis M. Escudero & Felipe Cortés-Ledesma, 2014. "ATM specifically mediates repair of double-strand breaks with blocked DNA ends," Nature Communications, Nature, vol. 5(1), pages 1-10, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4347
    DOI: 10.1038/ncomms4347
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