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Temporally selective contextual encoding in the dentate gyrus of the hippocampus

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  • L.M. Rangel

    (Program in Neurosciences, University of California
    Salk Institute for Biological Sciences
    Present address: Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215, USA)

  • A.S. Alexander

    (University of California)

  • J.B. Aimone

    (Salk Institute for Biological Sciences
    Present address: Cognitive Modeling Department, Sandia National Laboratories, Albuquerque, New Mexico 87185, USA)

  • J. Wiles

    (School of Information Technology and Electrical Engineering, University of Queensland)

  • F.H. Gage

    (Program in Neurosciences, University of California
    Salk Institute for Biological Sciences)

  • A.A. Chiba

    (Program in Neurosciences, University of California
    University of California)

  • L.K. Quinn

    (University of California)

Abstract

A recent model of the hippocampus predicts that the unique properties of the dentate gyrus allow for temporal separation of events. This temporal separation is accomplished in part through the continual generation of new neurons, which, due to a transient window of hyperexcitability, could allow for preferential encoding of information present during their development. Here we obtain in vivo electrophysiological recordings and identify a cell population exhibiting activity that is selective to single contexts when rats experience a long temporal separation between context exposures during training. This selectivity is attenuated as the temporal separation between context exposures is shortened and is further attenuated when neurogenesis is reduced. Our data reveal the existence of a temporal orthogonalizing neuronal code within the dentate gyrus, a hallmark feature of episodic memory.

Suggested Citation

  • L.M. Rangel & A.S. Alexander & J.B. Aimone & J. Wiles & F.H. Gage & A.A. Chiba & L.K. Quinn, 2014. "Temporally selective contextual encoding in the dentate gyrus of the hippocampus," Nature Communications, Nature, vol. 5(1), pages 1-9, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4181
    DOI: 10.1038/ncomms4181
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