IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms4164.html
   My bibliography  Save this article

Maspin is not required for embryonic development or tumour suppression

Author

Listed:
  • Sonia S. Y. Teoh

    (School of Biomedical Sciences, Monash University)

  • Jessica Vieusseux

    (School of Biomedical Sciences, Monash University)

  • Monica Prakash

    (School of Biomedical Sciences, Monash University)

  • Susan Berkowicz

    (School of Biomedical Sciences, Monash University)

  • Jennii Luu

    (School of Biomedical Sciences, Monash University)

  • Catherina H. Bird

    (School of Biomedical Sciences, Monash University)

  • Ruby H. P. Law

    (School of Biomedical Sciences, Monash University
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, School of Biomedical Sciences, Monash University)

  • Carlos Rosado

    (School of Biomedical Sciences, Monash University
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, School of Biomedical Sciences, Monash University)

  • John T. Price

    (School of Biomedical Sciences, Monash University)

  • James C. Whisstock

    (School of Biomedical Sciences, Monash University
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, School of Biomedical Sciences, Monash University)

  • Phillip I. Bird

    (School of Biomedical Sciences, Monash University)

Abstract

Maspin (SERPINB5) is accepted as an important tumour suppressor lost in many cancers. Consistent with a critical role in development or differentiation maspin knockout mice die during early embryogenesis, yet clinical data conflict on the prognostic utility of maspin expression. Here to reconcile these findings we made conditional knockout mice. Surprisingly, maspin knockout embryos develop into overtly normal animals. Contrary to original reports, maspin re-expression does not inhibit tumour growth or metastasis in vivo, or influence cell migration, invasion or survival in vitro. Bioinformatic analyses reveal that maspin is not commonly under-expressed in cancer, and that perturbation of genes near maspin may in fact explain poor survival in certain patient cohorts with low maspin expression.

Suggested Citation

  • Sonia S. Y. Teoh & Jessica Vieusseux & Monica Prakash & Susan Berkowicz & Jennii Luu & Catherina H. Bird & Ruby H. P. Law & Carlos Rosado & John T. Price & James C. Whisstock & Phillip I. Bird, 2014. "Maspin is not required for embryonic development or tumour suppression," Nature Communications, Nature, vol. 5(1), pages 1-9, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4164
    DOI: 10.1038/ncomms4164
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms4164
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms4164?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4164. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.