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Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus

Author

Listed:
  • Lunbiao Cui

    (Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention)

  • Di Liu

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
    Network Information Center, Institute of Microbiology, Chinese Academy of Sciences)

  • Weifeng Shi

    (School of Basic Medical Sciences, Taishan Medical College
    CAS Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences)

  • Jingcao Pan

    (Hangzhou Center for Disease Control and Prevention)

  • Xian Qi

    (Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention)

  • Xianbin Li

    (Shenzhen Institute of Advanced Technology, Chinese Academy of Science
    University of Chinese Academy of Sciences)

  • Xiling Guo

    (Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention)

  • Minghao Zhou

    (Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention)

  • Wei Li

    (Network Information Center, Institute of Microbiology, Chinese Academy of Sciences)

  • Jun Li

    (Hangzhou Center for Disease Control and Prevention)

  • Joel Haywood

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Haixia Xiao

    (Tianjin Institute of Biotechnology, Chinese Academy of Sciences)

  • Xinfen Yu

    (Hangzhou Center for Disease Control and Prevention)

  • Xiaoying Pu

    (Hangzhou Center for Disease Control and Prevention)

  • Ying Wu

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Huiyan Yu

    (Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention)

  • Kangchen Zhao

    (Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention)

  • Yefei Zhu

    (Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention)

  • Bin Wu

    (Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention)

  • Tao Jin

    (BGI-Shenzhen, Shenzhen)

  • Zhiyang Shi

    (Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention)

  • Fenyang Tang

    (Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention)

  • Fengcai Zhu

    (Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention)

  • Qinglan Sun

    (Network Information Center, Institute of Microbiology, Chinese Academy of Sciences)

  • Linhuan Wu

    (Network Information Center, Institute of Microbiology, Chinese Academy of Sciences)

  • Ruifu Yang

    (Beijing Institute of Microbiology and Epidemiology)

  • Jinghua Yan

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Fumin Lei

    (CAS Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences)

  • Baoli Zhu

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Wenjun Liu

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences)

  • Juncai Ma

    (Network Information Center, Institute of Microbiology, Chinese Academy of Sciences)

  • Hua Wang

    (Key Laboratory of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention)

  • George F. Gao

    (CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Beijing Institutes of Life Science, Chinese Academy of Sciences
    Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC))

Abstract

Influenza A (H7N9) virus has been causing human infections in China since February 2013, raising serious concerns of potential pandemics. Previous studies demonstrate that human infection is directly linked to live animal markets, and that the internal genes of the virus are derived from H9N2 viruses circulating in the Yangtze River Delta area in Eastern China. Here following analysis of 109 viruses, we show a much higher genetic heterogeneity of the H7N9 viruses than previously reported, with a total of 27 newly designated genotypes. Phylogenetic and genealogical inferences reveal that genotypes G0 and G2.6 dominantly co-circulate within poultry, with most human isolates belonging to the genotype G0. G0 viruses are also responsible for the inter- and intra-province transmissions, leading to the genesis of novel genotypes. These observations suggest the province-specific H9N2 virus gene pools increase the genetic diversity of H7N9 via dynamic reassortments and also imply that G0 has not gained overwhelming fitness and the virus continues to undergo reassortment.

Suggested Citation

  • Lunbiao Cui & Di Liu & Weifeng Shi & Jingcao Pan & Xian Qi & Xianbin Li & Xiling Guo & Minghao Zhou & Wei Li & Jun Li & Joel Haywood & Haixia Xiao & Xinfen Yu & Xiaoying Pu & Ying Wu & Huiyan Yu & Kan, 2014. "Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus," Nature Communications, Nature, vol. 5(1), pages 1-9, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4142
    DOI: 10.1038/ncomms4142
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