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Complex self-assembly of pyrimido[4,5-d]pyrimidine nucleoside supramolecular structures

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  • Hang Zhao

    (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University
    Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University)

  • Xiurong Guo

    (Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University)

  • Shiliang He

    (Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University)

  • Xin Zeng

    (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)

  • Xinglong Zhou

    (Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University)

  • Chaoliang Zhang

    (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)

  • Jing Hu

    (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)

  • Xiaohua Wu

    (Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University)

  • Zhihua Xing

    (Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University)

  • Liangyin Chu

    (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)

  • Yang He

    (Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University)

  • Qianming Chen

    (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)

Abstract

Supramolecular self-assembly is not only one of the chemical roots of biological structure but is also drawing attention in different industrial fields. Here we study the mechanism of the formation of a complex flower-shaped supramolecular structure of pyrimido[4,5-d]pyrimidine nucleosides by dynamic light scattering, scanning electron microscopy, differential scanning calorimetry, nuclear magnetic resonance and X-ray analysis. Upon removing the hydroxyl group of sugars, different flower-shaped superstructures can be produced. These works demonstrate that complex self-assembly can indeed be attained through hierarchical non-covalent interactions of single molecules. Furthermore, chimerical structures built from molecular recognition by these monomers indicate their potential in other fields if combined with other chemical entities.

Suggested Citation

  • Hang Zhao & Xiurong Guo & Shiliang He & Xin Zeng & Xinglong Zhou & Chaoliang Zhang & Jing Hu & Xiaohua Wu & Zhihua Xing & Liangyin Chu & Yang He & Qianming Chen, 2014. "Complex self-assembly of pyrimido[4,5-d]pyrimidine nucleoside supramolecular structures," Nature Communications, Nature, vol. 5(1), pages 1-11, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4108
    DOI: 10.1038/ncomms4108
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