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Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle

Author

Listed:
  • Daniel L. J. Thorek

    (The Johns Hopkins School of Medicine
    Memorial Sloan-Kettering Cancer Center (MSKCC))

  • David Ulmert

    (Memorial Sloan-Kettering Cancer Center (MSKCC)
    Lund University, Skåne University Hospital)

  • Ndeye-Fatou M. Diop

    (The City College of New York)

  • Mihaela E. Lupu

    (Memorial Sloan-Kettering Cancer Center (MSKCC))

  • Michael G. Doran

    (Memorial Sloan-Kettering Cancer Center (MSKCC))

  • Ruimin Huang

    (Memorial Sloan-Kettering Cancer Center (MSKCC))

  • Diane S. Abou

    (The Johns Hopkins School of Medicine)

  • Steven M. Larson

    (Memorial Sloan-Kettering Cancer Center (MSKCC)
    Program in Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center (MSKCC))

  • Jan Grimm

    (Memorial Sloan-Kettering Cancer Center (MSKCC)
    Program in Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center (MSKCC))

Abstract

The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with 99mTc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, 89Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling. Axillary drainage in naive mice and from healthy and tumour-bearing prostates was investigated. We demonstrate that 89Zr-ferumoxytol can be used for high-resolution tomographic studies of lymphatic drainage in preclinical disease models. This nanoparticle platform has significant translational potential to improve preoperative planning for nodal resection and tumour staging.

Suggested Citation

  • Daniel L. J. Thorek & David Ulmert & Ndeye-Fatou M. Diop & Mihaela E. Lupu & Michael G. Doran & Ruimin Huang & Diane S. Abou & Steven M. Larson & Jan Grimm, 2014. "Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle," Nature Communications, Nature, vol. 5(1), pages 1-9, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4097
    DOI: 10.1038/ncomms4097
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