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slanDCs selectively accumulate in carcinoma-draining lymph nodes and marginate metastatic cells

Author

Listed:
  • William Vermi

    (Section of Pathology, University of Brescia
    Washington University School of Medicine)

  • Alessandra Micheletti

    (Section of General Pathology, University of Verona)

  • Silvia Lonardi

    (Section of Pathology, University of Brescia)

  • Claudio Costantini

    (Section of General Pathology, University of Verona)

  • Federica Calzetti

    (Section of General Pathology, University of Verona)

  • Riccardo Nascimbeni

    (Section of Pathology, University of Brescia)

  • Mattia Bugatti

    (Section of Pathology, University of Brescia)

  • Manuela Codazzi

    (Section of Pathology, University of Brescia)

  • Patrick C. Pinter

    (Section of Otorhinolaryngology, University of Verona)

  • Knut Schäkel

    (University Hospital Heidelberg)

  • Nicola Tamassia

    (Section of General Pathology, University of Verona)

  • Marco A. Cassatella

    (Section of General Pathology, University of Verona)

Abstract

Dendritic cells (DCs) initiate adaptive immune responses to cancer cells by activating naive T lymphocytes. 6-sulfo LacNAc+ DCs (slanDCs) represent a distinct population of circulating and tissue proinflammatory DCs, whose role in cancer immune surveillance is unknown. Herein, by screening a large set of clinical samples, we demonstrate accumulation of slanDCs in metastatic tumour-draining lymph nodes (M-TDLN) from carcinoma patients. Remarkably, slanDCs are absent at the primary carcinoma site, while their selective nodal recruitment follows the arrival of cancer cells to M-TDLN. slanDCs surround metastatic carcinoma deposits in close proximity to dead cells and efficiently phagocytose tumour cells. In colon carcinoma patients, the contingent of circulating slanDCs remains intact and competent in terms of IL-12p70 and tumour necrosis factor alpha production, induction of T-cell proliferation and migratory capacity to a set of chemokines produced in M-TDLN. We conclude that activated slanDCs represent previously unrecognized players of nodal immune responses to cancer cells.

Suggested Citation

  • William Vermi & Alessandra Micheletti & Silvia Lonardi & Claudio Costantini & Federica Calzetti & Riccardo Nascimbeni & Mattia Bugatti & Manuela Codazzi & Patrick C. Pinter & Knut Schäkel & Nicola Tam, 2014. "slanDCs selectively accumulate in carcinoma-draining lymph nodes and marginate metastatic cells," Nature Communications, Nature, vol. 5(1), pages 1-16, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4029
    DOI: 10.1038/ncomms4029
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