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Multinuclear nanoliter one-dimensional and two-dimensional NMR spectroscopy with a single non-resonant microcoil

Author

Listed:
  • Raluca M. Fratila

    (Laboratory of SupraMolecular Chemistry & Technology, University of Twente)

  • M. Victoria Gomez

    (Instituto Regional de Investigación Científica Aplicada (IRICA), Universidad de Castilla-La Mancha, Avda. Camilo José Cela, s/n
    Fundación Parque Científico y Tecnológico de Albacete, Paseo de la Innovación, 1)

  • Stanislav Sýkora

    (Extra Byte, Via Raffaello Sanzio 22C)

  • Aldrik H. Velders

    (Laboratory of SupraMolecular Chemistry & Technology, University of Twente
    Instituto Regional de Investigación Científica Aplicada (IRICA), Universidad de Castilla-La Mancha, Avda. Camilo José Cela, s/n
    Laboratory of BioNanoTechnology, Wageningen University)

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical technique, but its low sensitivity and highly sophisticated, costly, equipment severely constrain more widespread applications. Here we show that a non-resonant planar transceiver microcoil integrated in a microfluidic chip (detection volume 25 nl) can detect different nuclides in the full broad-band range of Larmor frequencies (at 9.4 T from 61 to 400 MHz). Routine one-dimensional (1D) and two-dimensional (2D), homo- and heteronuclear experiments can be carried out using the broad-band coil set-up. Noteworthy, heteronuclear 2D experiments can be performed in a straightforward manner on virtually any combination of nuclides (from classical 1H–13C to more exotic combinations like 19F–31P) both in coupled and decoupled mode. Importantly, the concept of a non-resonant system provides magnetic field-independent NMR probes; moreover, the small-volume alleviates problems related to field inhomogeneity, making the broad-band coil an attractive option for, for example, portable and table-top NMR systems.

Suggested Citation

  • Raluca M. Fratila & M. Victoria Gomez & Stanislav Sýkora & Aldrik H. Velders, 2014. "Multinuclear nanoliter one-dimensional and two-dimensional NMR spectroscopy with a single non-resonant microcoil," Nature Communications, Nature, vol. 5(1), pages 1-8, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4025
    DOI: 10.1038/ncomms4025
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    Cited by:

    1. M. Victoria Gomez & Sander Baas & Aldrik H. Velders, 2023. "Multinuclear 1D and 2D NMR with 19F-Photo-CIDNP hyperpolarization in a microfluidic chip with untuned microcoil," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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