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Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo

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  • Michel G. Desarménien

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle
    INSERM, U661
    Universités de Montpellier 1 & 2, UMR-5203)

  • Carole Jourdan

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle
    INSERM, U661
    Universités de Montpellier 1 & 2, UMR-5203)

  • Bertrand Toutain

    (Department of Integrated Neurovascular and Mitochondrial Biology
    CNRS UMR6214
    INSERM U1083
    University of Angers)

  • Emilie Vessières

    (Department of Integrated Neurovascular and Mitochondrial Biology
    CNRS UMR6214
    INSERM U1083
    University of Angers)

  • Sheriar G. Hormuzdi

    (Ninewells Hospital and Medical School, University of Dundee)

  • Nathalie C. Guérineau

    (Department of Integrated Neurovascular and Mitochondrial Biology
    CNRS UMR6214
    INSERM U1083
    University of Angers)

Abstract

Elucidating the mechanisms whereby neuroendocrine tissues coordinate their input and output signals to ensure appropriate hormone secretion is currently a topical issue. In particular, whether a direct communication mediated by gap junctions between neurosecretory cells contributes to hormone release in vivo still remains unknown. Here we address this issue using a microsurgical approach allowing combined monitoring of adrenal catecholamine secretion and splanchnic nerve stimulation in anaesthetised mice. Pharmacological blockade of adrenal gap junctions by the uncoupling agent carbenoxolone reduces nerve stimulation-evoked catecholamine release in control mice and to a larger extent in stressed mice. In parallel, the gap junction-coupled cell network is extended in stressed mice. Altogether, this argues for a significant contribution of adrenomedullary gap junctions to catecholamine secretion in vivo. As such, gap junctional signalling appears to be a substantial component for neuroendocrine function in the adrenal medulla, as it may represent an additional lever regulating hormone release.

Suggested Citation

  • Michel G. Desarménien & Carole Jourdan & Bertrand Toutain & Emilie Vessières & Sheriar G. Hormuzdi & Nathalie C. Guérineau, 2013. "Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo," Nature Communications, Nature, vol. 4(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3938
    DOI: 10.1038/ncomms3938
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