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UTX coordinates steroid hormone-mediated autophagy and cell death

Author

Listed:
  • Donna Denton

    (Centre for Cancer Biology, SA Pathology
    University of South Australia)

  • May T. Aung-Htut

    (Centre for Cancer Biology, SA Pathology)

  • Nirmal Lorensuhewa

    (Centre for Cancer Biology, SA Pathology)

  • Shannon Nicolson

    (Centre for Cancer Biology, SA Pathology)

  • Wenying Zhu

    (Centre for Cancer Biology, SA Pathology)

  • Kathryn Mills

    (Centre for Cancer Biology, SA Pathology)

  • Dimitrios Cakouros

    (Centre for Cancer Biology, SA Pathology)

  • Andreas Bergmann

    (University of Massachusetts Medical School)

  • Sharad Kumar

    (Centre for Cancer Biology, SA Pathology
    University of South Australia
    The University of Adelaide)

Abstract

Correct spatial and temporal induction of numerous cell type-specific genes during development requires regulated removal of the repressive histone H3 lysine 27 trimethylation (H3K27me3) modification. Here we show that the H3K27me3 demethylase dUTX is required for hormone-mediated transcriptional regulation of apoptosis and autophagy genes during ecdysone-regulated programmed cell death of Drosophila salivary glands. We demonstrate that dUTX binds to the nuclear hormone receptor complex Ecdysone Receptor/Ultraspiracle, and is recruited to the promoters of key apoptosis and autophagy genes. Salivary gland cell death is delayed in dUTX mutants, with reduced caspase activity and autophagy that coincides with decreased apoptosis and autophagy gene transcripts. We further show that salivary gland degradation requires dUTX catalytic activity. Our findings provide evidence for an unanticipated role for UTX demethylase activity in regulating hormone-dependent cell death and demonstrate how a single transcriptional regulator can modulate a specific complex functional outcome during animal development.

Suggested Citation

  • Donna Denton & May T. Aung-Htut & Nirmal Lorensuhewa & Shannon Nicolson & Wenying Zhu & Kathryn Mills & Dimitrios Cakouros & Andreas Bergmann & Sharad Kumar, 2013. "UTX coordinates steroid hormone-mediated autophagy and cell death," Nature Communications, Nature, vol. 4(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3916
    DOI: 10.1038/ncomms3916
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