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Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis

Author

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  • Norio Suzuki

    (United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine)

  • Ikuo Hirano

    (Tohoku University Graduate School of Medicine)

  • Xiaoqing Pan

    (Tohoku University Graduate School of Medicine
    Tohoku Medical Megabank Organization)

  • Naoko Minegishi

    (Tohoku University Graduate School of Medicine
    Tohoku Medical Megabank Organization)

  • Masayuki Yamamoto

    (Tohoku University Graduate School of Medicine
    Tohoku Medical Megabank Organization)

Abstract

Erythropoietin (Epo) supports both primitive erythropoiesis in the yolk sac and definitive erythropoiesis in the fetal liver and bone marrow. Although definitive erythropoiesis requires kidney- and liver-secreted Epo, it is unclear which cells produce Epo for primitive erythropoiesis. Here we find neural Epo-producing (NEP) cells in mid-gestational stage embryos using mouse lines that express green fluorescent protein (GFP) under the Epo gene regulation. In these mice, GFP is expressed exclusively in a subpopulation of neural and neural crest cells at embryonic day 9.0 when Epo-deficient embryos exhibit abnormalities in primitive erythropoiesis. The GFP-positive NEP cells express Epo mRNA and the ex vivo culture of embryonic day 8.5 neural tubes results in the secretion of Epo, which is able to induce the proliferation and differentiation of yolk sac-derived erythroid cells. These results thus suggest that NEP cells secrete Epo and might support the development of primitive erythropoiesis.

Suggested Citation

  • Norio Suzuki & Ikuo Hirano & Xiaoqing Pan & Naoko Minegishi & Masayuki Yamamoto, 2013. "Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis," Nature Communications, Nature, vol. 4(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3902
    DOI: 10.1038/ncomms3902
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