IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms3836.html
   My bibliography  Save this article

Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation

Author

Listed:
  • Katie J. Ewer

    (The Jenner Institute Laboratories, University of Oxford)

  • Geraldine A. O’Hara

    (Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital)

  • Christopher J. A. Duncan

    (Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital)

  • Katharine A. Collins

    (The Jenner Institute Laboratories, University of Oxford)

  • Susanne H. Sheehy

    (Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital)

  • Arturo Reyes-Sandoval

    (The Jenner Institute Laboratories, University of Oxford)

  • Anna L. Goodman

    (The Jenner Institute Laboratories, University of Oxford
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital)

  • Nick J. Edwards

    (The Jenner Institute Laboratories, University of Oxford)

  • Sean C. Elias

    (The Jenner Institute Laboratories, University of Oxford)

  • Fenella D. Halstead

    (The Jenner Institute Laboratories, University of Oxford)

  • Rhea J. Longley

    (The Jenner Institute Laboratories, University of Oxford)

  • Rosalind Rowland

    (Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital)

  • Ian D. Poulton

    (Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital)

  • Simon J. Draper

    (The Jenner Institute Laboratories, University of Oxford)

  • Andrew M. Blagborough

    (Imperial College London)

  • Eleanor Berrie

    (Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital)

  • Sarah Moyle

    (Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital)

  • Nicola Williams

    (Centre for Statistics in Medicine)

  • Loredana Siani

    (Okairos)

  • Antonella Folgori

    (Okairos)

  • Stefano Colloca

    (Okairos)

  • Robert E. Sinden

    (The Jenner Institute Laboratories, University of Oxford
    Imperial College London)

  • Alison M. Lawrie

    (Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital)

  • Riccardo Cortese

    (Okairos)

  • Sarah C. Gilbert

    (The Jenner Institute Laboratories, University of Oxford)

  • Alfredo Nicosia

    (Okairos
    CEINGE
    University of Naples Federico II)

  • Adrian V. S. Hill

    (The Jenner Institute Laboratories, University of Oxford
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital)

Abstract

Induction of antigen-specific CD8+ T cells offers the prospect of immunization against many infectious diseases, but no subunit vaccine has induced CD8+ T cells that correlate with efficacy in humans. Here we demonstrate that a replication-deficient chimpanzee adenovirus vector followed by a modified vaccinia virus Ankara booster induces exceptionally high frequency T-cell responses (median >2400 SFC/106 peripheral blood mononuclear cells) to the liver-stage Plasmodium falciparum malaria antigen ME-TRAP. It induces sterile protective efficacy against heterologous strain sporozoites in three vaccinees (3/14, 21%), and delays time to patency through substantial reduction of liver-stage parasite burden in five more (5/14, 36%), P=0.008 compared with controls. The frequency of monofunctional interferon-γ-producing CD8+ T cells, but not antibodies, correlates with sterile protection and delay in time to patency (Pcorrected=0.005). Vaccine-induced CD8+ T cells provide protection against human malaria, suggesting that a major limitation of previous vaccination approaches has been the insufficient magnitude of induced T cells.

Suggested Citation

  • Katie J. Ewer & Geraldine A. O’Hara & Christopher J. A. Duncan & Katharine A. Collins & Susanne H. Sheehy & Arturo Reyes-Sandoval & Anna L. Goodman & Nick J. Edwards & Sean C. Elias & Fenella D. Halst, 2013. "Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation," Nature Communications, Nature, vol. 4(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3836
    DOI: 10.1038/ncomms3836
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms3836
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms3836?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3836. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.