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Arabidopsis SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity

Author

Listed:
  • Stefano Pietra

    (Umeå Plant Science Centre, Umeå University)

  • Anna Gustavsson

    (Umeå Plant Science Centre, Umeå University)

  • Christian Kiefer

    (Umeå Plant Science Centre, Umeå University)

  • Lothar Kalmbach

    (Umeå Plant Science Centre, Umeå University
    Present addresses: Department of Plant Molecular Biology, University of Lausanne, UNIL-Sorge, Biophore Building, 1015 Lausanne, Switzerland)

  • Per Hörstedt

    (Umeå Core Facility Electron Microscopy, Umeå University)

  • Yoshihisa Ikeda

    (Umeå Plant Science Centre, Umeå University
    Present address: Centre of the Region Haná for Biotechnological and Agricultural Research, Department of Molecular Biology, Faculty of Science, Palacký University Olomouc, Šlechtitelů 11, 78371 Olomouc, Czech Republic)

  • Anna N. Stepanova

    (North Carolina State University)

  • Jose M. Alonso

    (North Carolina State University)

  • Markus Grebe

    (Umeå Plant Science Centre, Umeå University)

Abstract

The orientation of cell division and the coordination of cell polarity within the plane of the tissue layer (planar polarity) contribute to shape diverse multicellular organisms. The root of Arabidopsis thaliana displays regularly oriented cell divisions, cell elongation and planar polarity providing a plant model system to study these processes. Here we report that the SABRE protein, which shares similarity with proteins of unknown function throughout eukaryotes, has important roles in orienting cell division and planar polarity. SABRE localizes at the plasma membrane, endomembranes, mitotic spindle and cell plate. SABRE stabilizes the orientation of CLASP-labelled preprophase band microtubules predicting the cell division plane, and of cortical microtubules driving cell elongation. During planar polarity establishment, sabre is epistatic to clasp at directing polar membrane domains of Rho-of-plant GTPases. Our findings mechanistically link SABRE to CLASP-dependent microtubule organization, shedding new light on the function of SABRE-related proteins in eukaryotes.

Suggested Citation

  • Stefano Pietra & Anna Gustavsson & Christian Kiefer & Lothar Kalmbach & Per Hörstedt & Yoshihisa Ikeda & Anna N. Stepanova & Jose M. Alonso & Markus Grebe, 2013. "Arabidopsis SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity," Nature Communications, Nature, vol. 4(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3779
    DOI: 10.1038/ncomms3779
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