Author
Listed:
- Dai Mitsushima
(Yokohama City University Graduate School of Medicine
Kanagawa Dental University
Yamaguchi University Graduate School of Medicine)
- Akane Sano
(Yokohama City University Graduate School of Medicine)
- Takuya Takahashi
(Yokohama City University Graduate School of Medicine
Albert Einstein College of Medicine)
Abstract
Learning induces plastic changes in synapses. However, the regulatory molecules that orchestrate learning-induced synaptic changes are largely unknown. Although it is well established that cholinergic inputs from the medial septum modulate learning and memory, evidence for the cholinergic regulation of learning-induced synaptic plasticity is lacking. Here we find that the activation of muscarinic acetylcholine (ACh) receptors (mAChRs) mediates the contextual fear learning-driven strengthening of hippocampal excitatory pyramidal synapses through the synaptic incorporation of AMPA-type glutamate receptors (AMPARs). Contextual fear learning also enhances the strength of inhibitory synapses on hippocampal pyramidal CA1 neurons, in a manner mediated by the activation of, not mAChRs, but, nicotinic AChRs (nAChRs). We observe a significant correlation between the learning-induced increases in excitatory and inhibitory synaptic strength at individual pyramidal neurons. Understanding the mechanisms underlying cholinergic regulation of learning-induced hippocampal synaptic plasticity may help the development of new therapies for cognitive disorders.
Suggested Citation
Dai Mitsushima & Akane Sano & Takuya Takahashi, 2013.
"A cholinergic trigger drives learning-induced plasticity at hippocampal synapses,"
Nature Communications, Nature, vol. 4(1), pages 1-10, December.
Handle:
RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3760
DOI: 10.1038/ncomms3760
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