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Involvement of parental imprinting in the antisense regulation of onco-miR-372-373

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  • Yonatan Stelzer

    (Stem Cell Unit, Silberman Institute of Life Sciences, The Hebrew University)

  • Ido Sagi

    (Stem Cell Unit, Silberman Institute of Life Sciences, The Hebrew University)

  • Nissim Benvenisty

    (Stem Cell Unit, Silberman Institute of Life Sciences, The Hebrew University)

Abstract

The monoallelic nature of imprinted genes renders them highly susceptible to genetic and epigenetic perturbations, potentially resulting in transformation and disease. Here we show, using parthenogenetic induced pluripotent stem cells, an imprinted transcript that serves as an antisense regulator of onco-miR-372-3 (named anti-miR-371-3). As miR-372-3 have been shown to have an oncogenic role in testicular germ cell tumours, we study the involvement of their antisense transcript in these cells. Our results suggest that hypermethylation, leading to loss-of-expression of the imprinted antisense transcript, contributes to tumorigenic transformation by affecting the downstream target LATS2. Finally, we provide evidence for a tumour suppressive role of anti-miR-371-3, as its overexpression in tumour cells results in cell growth arrest and apoptosis, and prevents tumour formation on injection into immunodeficient mice.

Suggested Citation

  • Yonatan Stelzer & Ido Sagi & Nissim Benvenisty, 2013. "Involvement of parental imprinting in the antisense regulation of onco-miR-372-373," Nature Communications, Nature, vol. 4(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3724
    DOI: 10.1038/ncomms3724
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