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Chimeric viruses blur the borders between the major groups of eukaryotic single-stranded DNA viruses

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  • Simon Roux

    (Laboratoire ‘Microorganismes: Génome et Environnement’, Clermont Université, Université Blaise Pascal
    CNRS UMR 6023, LMGE)

  • François Enault

    (Laboratoire ‘Microorganismes: Génome et Environnement’, Clermont Université, Université Blaise Pascal
    CNRS UMR 6023, LMGE)

  • Gisèle Bronner

    (Laboratoire ‘Microorganismes: Génome et Environnement’, Clermont Université, Université Blaise Pascal
    CNRS UMR 6023, LMGE)

  • Daniel Vaulot

    (UPMC (Paris-06) and CNRS, UMR 7144, Station Biologique)

  • Patrick Forterre

    (Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur
    Laboratoire de Biologie Moléculaire du Gène chez les Extrêmophiles, Institut de Génétique et Microbiologie, CNRS UMR 8621, Université Paris Sud)

  • Mart Krupovic

    (Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur)

Abstract

Metagenomic studies have uncovered an astonishing diversity of ssDNA viruses encoding replication proteins (Reps) related to those of eukaryotic Circoviridae, Geminiviridae or Nanoviridae; however, exact evolutionary relationships among these viruses remain obscure. Recently, a unique chimeric virus (CHIV) genome, which has apparently emerged via recombination between ssRNA and ssDNA viruses, has been discovered. Here we report on the assembly of 13 new CHIV genomes recovered from various environments. Our results indicate a single event of capsid protein (CP) gene capture from an RNA virus in the history of this virus group. The domestication of the CP gene was followed by an unprecedented recurrent replacement of the Rep genes in CHIVs with distant counterparts from diverse ssDNA viruses. We suggest that parasitic and symbiotic interactions between unicellular eukaryotes were central for the emergence of CHIVs and that such turbulent evolution was primarily dictated by incongruence between the CP and Rep proteins.

Suggested Citation

  • Simon Roux & François Enault & Gisèle Bronner & Daniel Vaulot & Patrick Forterre & Mart Krupovic, 2013. "Chimeric viruses blur the borders between the major groups of eukaryotic single-stranded DNA viruses," Nature Communications, Nature, vol. 4(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3700
    DOI: 10.1038/ncomms3700
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