Author
Listed:
- Kuniko Takagi
(Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University
Kagoshima University Graduate School of Medical and Dental Sciences)
- Romain Legrand
(Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University)
- Akihiro Asakawa
(Kagoshima University Graduate School of Medical and Dental Sciences)
- Haruka Amitani
(Kagoshima University Graduate School of Medical and Dental Sciences)
- Marie François
(Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University)
- Naouel Tennoune
(Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University)
- Moïse Coëffier
(Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University
Rouen University Hospital, CHU Charles Nicolle)
- Sophie Claeyssens
(Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University
Rouen University Hospital, CHU Charles Nicolle)
- Jean-Claude do Rego
(Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University
Animal Behavior Platform (SCAC), IRIB)
- Pierre Déchelotte
(Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University
Rouen University Hospital, CHU Charles Nicolle)
- Akio Inui
(Kagoshima University Graduate School of Medical and Dental Sciences)
- Sergueï O. Fetissov
(Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University)
Abstract
Obese individuals often have increased appetite despite normal plasma levels of the main orexigenic hormone ghrelin. Here we show that ghrelin degradation in the plasma is inhibited by ghrelin-reactive IgG immunoglobulins, which display increased binding affinity to ghrelin in obese patients and mice. Co-administration of ghrelin together with IgG from obese individuals, but not with IgG from anorectic or control patients, increases food intake in rats. Similarly, chronic injections of ghrelin together with IgG from ob/ob mice increase food intake, meal frequency and total lean body mass of mice. These data reveal that in both obese humans and mice, IgG with increased affinity for ghrelin enhances ghrelin’s orexigenic effect, which may contribute to increased appetite and overeating.
Suggested Citation
Kuniko Takagi & Romain Legrand & Akihiro Asakawa & Haruka Amitani & Marie François & Naouel Tennoune & Moïse Coëffier & Sophie Claeyssens & Jean-Claude do Rego & Pierre Déchelotte & Akio Inui & Sergue, 2013.
"Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans,"
Nature Communications, Nature, vol. 4(1), pages 1-11, December.
Handle:
RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3685
DOI: 10.1038/ncomms3685
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