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Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings

Author

Listed:
  • Han Wen

    (National Institutes of Health)

  • Andrew A. Gomella

    (National Institutes of Health)

  • Ajay Patel

    (National Institutes of Health)

  • Susanna K. Lynch

    (National Institutes of Health)

  • Nicole Y. Morgan

    (National Institutes of Health)

  • Stasia A. Anderson

    (National Institutes of Health)

  • Eric E. Bennett

    (National Institutes of Health)

  • Xianghui Xiao

    (Advanced Photon Source, Argonne National Laboratory)

  • Chian Liu

    (Advanced Photon Source, Argonne National Laboratory)

  • Douglas E. Wolfe

    (Penn State University, State College)

Abstract

Hard X-ray phase-contrast imaging characterizes the electron density distribution in an object without the need for radiation absorption. The power of phase contrast to resolve subtle changes, such as those in soft tissue structures, lies in its ability to detect minute refractive bending of X-rays. Here we report a far-field, two-arm interferometer based on the new nanometric phase gratings, which can detect X-ray refraction with subnanoradian sensitivity, and at the same time overcomes the fundamental limitation of ultra-narrow bandwidths (Δλ/λ~10−4) of the current, most sensitive methods based on crystal interferometers. On a 1.5% bandwidth synchrotron source, we demonstrate clear visualization of blood vessels in unstained mouse organs in simple projection views, with over an order-of-magnitude higher phase contrast than current near-field grating interferometers.

Suggested Citation

  • Han Wen & Andrew A. Gomella & Ajay Patel & Susanna K. Lynch & Nicole Y. Morgan & Stasia A. Anderson & Eric E. Bennett & Xianghui Xiao & Chian Liu & Douglas E. Wolfe, 2013. "Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings," Nature Communications, Nature, vol. 4(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3659
    DOI: 10.1038/ncomms3659
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    Cited by:

    1. Katherine J Harmon & Eric E Bennett & Andrew A Gomella & Han Wen, 2014. "Efficient Decoding of 2D Structured Illumination with Linear Phase Stepping in X-Ray Phase Contrast and Dark-Field Imaging," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-6, January.

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