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Circuit reactivation dynamically regulates synaptic plasticity in neocortex

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  • Peter B. Kruskal

    (Committee on Computational Neuroscience, University of Chicago)

  • Lucy Li

    (University of Chicago)

  • Jason N MacLean

    (Committee on Computational Neuroscience, University of Chicago
    University of Chicago)

Abstract

Circuit reactivations involve a stereotyped sequence of neuronal firing and have been behaviourally linked to memory consolidation. Here we use multiphoton imaging and patch-clamp recording, and observe sparse and stereotyped circuit reactivations that correspond to UP states within active neurons. To evaluate the effect of the circuit on synaptic plasticity, we trigger a single spike-timing-dependent plasticity (STDP) pairing once per circuit reactivation. The pairings reliably fall within a particular epoch of the circuit sequence and result in long-term potentiation. During reactivation, the amplitude of plasticity significantly correlates with the preceding 20–25 ms of membrane depolarization rather than the depolarization at the time of pairing. This circuit-dependent plasticity provides a natural constraint on synaptic potentiation, regulating the inherent instability of STDP in an assembly phase-sequence model. Subthreshold voltage during endogenous circuit reactivations provides a critical informative context for plasticity and facilitates the stable consolidation of a spatiotemporal sequence.

Suggested Citation

  • Peter B. Kruskal & Lucy Li & Jason N MacLean, 2013. "Circuit reactivation dynamically regulates synaptic plasticity in neocortex," Nature Communications, Nature, vol. 4(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3574
    DOI: 10.1038/ncomms3574
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