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Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma

Author

Listed:
  • Matthew Frampton

    (Institute of Cancer Research)

  • Miguel Inacio da Silva Filho

    (German Cancer Research Centre)

  • Peter Broderick

    (Institute of Cancer Research)

  • Hauke Thomsen

    (German Cancer Research Centre)

  • Asta Försti

    (German Cancer Research Centre
    Center for Primary Health Care Research, Lund University)

  • Jayaram Vijayakrishnan

    (Institute of Cancer Research)

  • Rosie Cooke

    (Institute of Cancer Research)

  • Victor Enciso-Mora

    (Institute of Cancer Research)

  • Per Hoffmann

    (Institute of Human Genetics, University of Bonn
    Genomics Research Group, Medical Genetics, University Hospital Basel)

  • Markus M. Nöthen

    (Institute of Human Genetics, University of Bonn
    German Center for Neurodegenerative Diseases (DZNE))

  • Amy Lloyd

    (Institute of Cancer Research)

  • Amy Holroyd

    (Institute of Cancer Research)

  • Lewin Eisele

    (Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg–Essen)

  • Karl-Heinz Jöckel

    (Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg–Essen)

  • Sabine Ponader

    (University Hospital of Cologne)

  • Elke Pogge von Strandmann

    (University Hospital of Cologne)

  • Tracy Lightfoot

    (Epidemiology and Cancer Statistics Group, University of York)

  • Eve Roman

    (Epidemiology and Cancer Statistics Group, University of York)

  • Annette Lake

    (MRC University of Glasgow Centre for Virus Research)

  • Dorothy Montgomery

    (MRC University of Glasgow Centre for Virus Research)

  • Ruth F. Jarrett

    (MRC University of Glasgow Centre for Virus Research)

  • Anthony J. Swerdlow

    (Institute of Cancer Research
    Institute of Cancer Research)

  • Andreas Engert

    (University Hospital of Cologne)

  • Kari Hemminki

    (German Cancer Research Centre
    Center for Primary Health Care Research, Lund University)

  • Richard S. Houlston

    (Institute of Cancer Research)

Abstract

In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14 × 10−12, odds ratio (OR)=1.26) and 6q23.3 (rs7745098; P=3.42 × 10−9, OR=1.21). rs3806624 localizes 5′ to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.

Suggested Citation

  • Matthew Frampton & Miguel Inacio da Silva Filho & Peter Broderick & Hauke Thomsen & Asta Försti & Jayaram Vijayakrishnan & Rosie Cooke & Victor Enciso-Mora & Per Hoffmann & Markus M. Nöthen & Amy Lloy, 2013. "Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma," Nature Communications, Nature, vol. 4(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3549
    DOI: 10.1038/ncomms3549
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