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Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes

Author

Listed:
  • Ji Hun Kim

    (Murdoch Childrens Research Institute, Royal Children’s Hospital
    University of Melbourne)

  • Tao Zhang

    (Murdoch Childrens Research Institute, Royal Children’s Hospital
    University of Melbourne)

  • Nicholas C. Wong

    (Murdoch Childrens Research Institute, Royal Children’s Hospital
    Ludwig Institute of Cancer Research, Olivia Newton John Cancer and Wellness Centre, Austin Hospital
    University of Melbourne)

  • Nadia Davidson

    (Murdoch Childrens Research Institute, Royal Children’s Hospital)

  • Jovana Maksimovic

    (Murdoch Childrens Research Institute, Royal Children’s Hospital)

  • Alicia Oshlack

    (Murdoch Childrens Research Institute, Royal Children’s Hospital
    University of Melbourne)

  • William C. Earnshaw

    (Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh)

  • Paul Kalitsis

    (Murdoch Childrens Research Institute, Royal Children’s Hospital
    University of Melbourne)

  • Damien F. Hudson

    (Murdoch Childrens Research Institute, Royal Children’s Hospital
    University of Melbourne)

Abstract

The condensin complex is essential for correct packaging and segregation of chromosomes during mitosis and meiosis in all eukaryotes. To date, the genome-wide location and the nature of condensin-binding sites have remained elusive in vertebrates. Here we report the genome-wide map of condensin I in chicken DT40 cells. Unexpectedly, we find that condensin I binds predominantly to promoter sequences in mitotic cells. We also find a striking enrichment at both centromeres and telomeres, highlighting the importance of the complex in chromosome segregation. Taken together, the results show that condensin I is largely absent from heterochromatic regions. This map of the condensin I binding sites on the chicken genome reveals that patterns of condensin distribution on chromosomes are conserved from prokaryotes, through yeasts to vertebrates. Thus in three kingdoms of life, condensin is enriched on promoters of actively transcribed genes and at loci important for chromosome segregation.

Suggested Citation

  • Ji Hun Kim & Tao Zhang & Nicholas C. Wong & Nadia Davidson & Jovana Maksimovic & Alicia Oshlack & William C. Earnshaw & Paul Kalitsis & Damien F. Hudson, 2013. "Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes," Nature Communications, Nature, vol. 4(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3537
    DOI: 10.1038/ncomms3537
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