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Functional salivary gland regeneration by transplantation of a bioengineered organ germ

Author

Listed:
  • Miho Ogawa

    (Research Institute for Science and Technology, Tokyo University of Science
    Organ Technologies Inc)

  • Masamitsu Oshima

    (Research Institute for Science and Technology, Tokyo University of Science)

  • Aya Imamura

    (Graduate School of Industrial Science and Technology, Tokyo University of Science)

  • Yurie Sekine

    (Graduate School of Industrial Science and Technology, Tokyo University of Science)

  • Kentaro Ishida

    (Research Institute for Science and Technology, Tokyo University of Science)

  • Kentaro Yamashita

    (Graduate School of Industrial Science and Technology, Tokyo University of Science)

  • Kei Nakajima

    (Tokyo Dental College)

  • Masatoshi Hirayama

    (Keio University School of Medicine)

  • Tetsuhiko Tachikawa

    (Showa University School of Dentistry)

  • Takashi Tsuji

    (Research Institute for Science and Technology, Tokyo University of Science
    Organ Technologies Inc
    Graduate School of Industrial Science and Technology, Tokyo University of Science)

Abstract

Salivary gland hypofunction, also known as xerostomia, occurs as a result of radiation therapy for head cancer, Sjögren’s syndrome or aging, and can cause a variety of critical oral health issues, including dental decay, bacterial infection, mastication dysfunction, swallowing dysfunction and reduced quality of life. Here we demonstrate the full functional regeneration of a salivary gland that reproduces the morphogenesis induced by reciprocal epithelial and mesenchymal interactions through the orthotopic transplantation of a bioengineered salivary gland germ as a regenerative organ replacement therapy. The bioengineered germ develops into a mature gland through acinar formations with a myoepithelium and innervation. The bioengineered submandibular gland produces saliva in response to the administration of pilocarpine and gustatory stimulation by citrate, protects against oral bacterial infection and restores normal swallowing in a salivary gland-defective mouse model. This study thus provides a proof-of-concept for bioengineered salivary gland regeneration as a potential treatment of xerostomia.

Suggested Citation

  • Miho Ogawa & Masamitsu Oshima & Aya Imamura & Yurie Sekine & Kentaro Ishida & Kentaro Yamashita & Kei Nakajima & Masatoshi Hirayama & Tetsuhiko Tachikawa & Takashi Tsuji, 2013. "Functional salivary gland regeneration by transplantation of a bioengineered organ germ," Nature Communications, Nature, vol. 4(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3498
    DOI: 10.1038/ncomms3498
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