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Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ

Author

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  • Masatoshi Hirayama

    (School of Medicine, Keio University
    Research Institute for Science and Technology, Tokyo University of Science)

  • Miho Ogawa

    (Research Institute for Science and Technology, Tokyo University of Science
    Organ Technologies Inc.)

  • Masamitsu Oshima

    (Research Institute for Science and Technology, Tokyo University of Science)

  • Yurie Sekine

    (Graduate School of Industrial Science and Technology, Tokyo University of Science)

  • Kentaro Ishida

    (Research Institute for Science and Technology, Tokyo University of Science)

  • Kentaro Yamashita

    (Graduate School of Industrial Science and Technology, Tokyo University of Science)

  • Kazutaka Ikeda

    (Institute for Advanced Biosciences, Keio University)

  • Shigeto Shimmura

    (School of Medicine, Keio University)

  • Tetsuya Kawakita

    (School of Medicine, Keio University)

  • Kazuo Tsubota

    (School of Medicine, Keio University)

  • Takashi Tsuji

    (Research Institute for Science and Technology, Tokyo University of Science
    Organ Technologies Inc.
    Graduate School of Industrial Science and Technology, Tokyo University of Science)

Abstract

The lacrimal gland has a multifaceted role in maintaining a homeostatic microenvironment for a healthy ocular surface via tear secretion. Dry-eye disease, which is caused by lacrimal gland dysfunction, is one of the most prevalent eye diseases that cause corneal epithelial damage and results in significant loss of vision and a reduction in the quality of life. Here we demonstrate orthotopic transplantation of bioengineered lacrimal gland germs into adult mice with an extra-orbital lacrimal gland defect, a mouse model that mimics the corneal epithelial damage caused by lacrimal gland dysfunction. The bioengineered lacrimal gland germs and harderian gland germs both develop in vivo and achieve sufficient physiological functionality, including tear production in response to nervous stimulation and ocular surface protection. This study demonstrates the potential for bioengineered organ replacement to functionally restore the lacrimal gland.

Suggested Citation

  • Masatoshi Hirayama & Miho Ogawa & Masamitsu Oshima & Yurie Sekine & Kentaro Ishida & Kentaro Yamashita & Kazutaka Ikeda & Shigeto Shimmura & Tetsuya Kawakita & Kazuo Tsubota & Takashi Tsuji, 2013. "Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ," Nature Communications, Nature, vol. 4(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3497
    DOI: 10.1038/ncomms3497
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