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Hydrogenosomes in the diplomonad Spironucleus salmonicida

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  • Jon Jerlström-Hultqvist

    (Uppsala University, BMC, Box 596, SE-751 24 Uppsala, Sweden
    Present address: Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, SE-751 23, Uppsala, Sweden)

  • Elin Einarsson

    (Uppsala University, BMC, Box 596, SE-751 24 Uppsala, Sweden)

  • Feifei Xu

    (Uppsala University, BMC, Box 596, SE-751 24 Uppsala, Sweden)

  • Karin Hjort

    (Uppsala University, BMC, Box 596, SE-751 24 Uppsala, Sweden
    Present address: Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, SE-751 23, Uppsala, Sweden)

  • Bo Ek

    (Analytical Chemistry, Uppsala University, BMC, Box 599, SE-751 24 Uppsala, Sweden)

  • Daniel Steinhauf

    (Uppsala University, BMC, Box 596, SE-751 24 Uppsala, Sweden
    Present address: Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, SE-751 23, Uppsala, Sweden)

  • Kjell Hultenby

    (Karolinska Institutet, EMIL enheten, F52, SE-141 86, Stockholm, Sweden)

  • Jonas Bergquist

    (Analytical Chemistry, Uppsala University, BMC, Box 599, SE-751 24 Uppsala, Sweden)

  • Jan O. Andersson

    (Uppsala University, BMC, Box 596, SE-751 24 Uppsala, Sweden)

  • Staffan G. Svärd

    (Uppsala University, BMC, Box 596, SE-751 24 Uppsala, Sweden)

Abstract

Acquisition of the mitochondrion is a key event in the evolution of the eukaryotic cell, but diversification of the organelle has occurred during eukaryotic evolution. One example of such mitochondria-related organelles (MROs) are hydrogenosomes, which produce ATP by substrate-level phosphorylation with hydrogen as a byproduct. The diplomonad parasite Giardia intestinalis harbours mitosomes, another type of MRO. Here we identify MROs in the salmon parasite Spironucleus salmonicida with similar protein import and Fe–S cluster assembly machineries as in Giardia mitosomes. We find that hydrogen production is prevalent in the diplomonad genus Spironucleus, and that S. salmonicida MROs contain enzymes characteristic of hydrogenosomes. Evolutionary analyses of known hydrogenosomal components indicate their presence in the diplomonad ancestor, and subsequent loss in Giardia. Our results suggest that hydrogenosomes are metabolic adaptations predating the split between parabasalids and diplomonads, which is deeper than the split between animals and fungi in the eukaryotic tree.

Suggested Citation

  • Jon Jerlström-Hultqvist & Elin Einarsson & Feifei Xu & Karin Hjort & Bo Ek & Daniel Steinhauf & Kjell Hultenby & Jonas Bergquist & Jan O. Andersson & Staffan G. Svärd, 2013. "Hydrogenosomes in the diplomonad Spironucleus salmonicida," Nature Communications, Nature, vol. 4(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3493
    DOI: 10.1038/ncomms3493
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