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Activation of the central nervous system induced by micro-magnetic stimulation

Author

Listed:
  • Hyun-Joo Park

    (Cleveland Clinic, 9500 Euclid Avenue)

  • Giorgio Bonmassar

    (A.A. Martinos Center, Harvard Medical School, Massachusetts General Hospital)

  • James A. Kaltenbach

    (Cleveland Clinic, 9500 Euclid Avenue
    Head and Neck Institute, Cleveland Clinic)

  • Andre G. Machado

    (Cleveland Clinic, 9500 Euclid Avenue
    Center for Neurological Restoration, Cleveland Clinic)

  • Nauman F. Manzoor

    (Cleveland Clinic, 9500 Euclid Avenue)

  • John T. Gale

    (Cleveland Clinic, 9500 Euclid Avenue
    Center for Neurological Restoration, Cleveland Clinic)

Abstract

Electrical and transcranial magnetic stimulations have proven to be therapeutically beneficial for patients suffering from neurological disorders. Moreover, these stimulation technologies have provided invaluable tools for investigating nervous system functions. Despite this success, these technologies have technical and practical limitations impeding the maximization of their full clinical and preclinical potential. Recently, micro-magnetic stimulation, which may offer advantages over electrical and transcranial magnetic stimulation, has proven effective in activating the neuronal circuitry of the retina in vitro. Here we demonstrate that this technology is also capable of activating neuronal circuitry on a systems level using an in vivo preparation. Specifically, the application of micro-magnetic fields to the dorsal cochlear nucleus activates inferior colliculus neurons. Additionally, we demonstrate the efficacy and characteristics of activation using different magnetic stimulation parameters. These findings provide a rationale for further exploration of micro-magnetic stimulation as a prospective tool for clinical and preclinical applications.

Suggested Citation

  • Hyun-Joo Park & Giorgio Bonmassar & James A. Kaltenbach & Andre G. Machado & Nauman F. Manzoor & John T. Gale, 2013. "Activation of the central nervous system induced by micro-magnetic stimulation," Nature Communications, Nature, vol. 4(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3463
    DOI: 10.1038/ncomms3463
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