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Tumour angiogenesis regulation by the miR-200 family

Author

Listed:
  • Chad V. Pecot

    (Head and Neck Oncology, The University of Texas MD Anderson Cancer Center)

  • Rajesha Rupaimoole

    (The University of Texas MD Anderson Cancer Center)

  • Da Yang

    (The University of Texas MD Anderson Cancer Center)

  • Rehan Akbani

    (The University of Texas MD Anderson Cancer Center)

  • Cristina Ivan

    (The University of Texas MD Anderson Cancer Center
    Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center)

  • Chunhua Lu

    (The University of Texas MD Anderson Cancer Center)

  • Sherry Wu

    (The University of Texas MD Anderson Cancer Center)

  • Hee-Dong Han

    (The University of Texas MD Anderson Cancer Center)

  • Maitri Y. Shah

    (The University of Texas MD Anderson Cancer Center)

  • Cristian Rodriguez-Aguayo

    (The University of Texas MD Anderson Cancer Center)

  • Justin Bottsford-Miller

    (The University of Texas MD Anderson Cancer Center)

  • Yuexin Liu

    (The University of Texas MD Anderson Cancer Center)

  • Sang Bae Kim

    (The University of Texas MD Anderson Cancer Center)

  • Anna Unruh

    (The University of Texas MD Anderson Cancer Center)

  • Vianey Gonzalez-Villasana

    (The University of Texas MD Anderson Cancer Center)

  • Li Huang

    (The University of Texas MD Anderson Cancer Center)

  • Behrouz Zand

    (The University of Texas MD Anderson Cancer Center)

  • Myrthala Moreno-Smith

    (The University of Texas MD Anderson Cancer Center)

  • Lingegowda S. Mangala

    (The University of Texas MD Anderson Cancer Center
    Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center)

  • Morgan Taylor

    (The University of Texas MD Anderson Cancer Center)

  • Heather J. Dalton

    (The University of Texas MD Anderson Cancer Center)

  • Vasudha Sehgal

    (The University of Texas MD Anderson Cancer Center)

  • Yunfei Wen

    (The University of Texas MD Anderson Cancer Center)

  • Yu Kang

    (The University of Texas MD Anderson Cancer Center)

  • Keith A. Baggerly

    (The University of Texas MD Anderson Cancer Center)

  • Ju-Seog Lee

    (The University of Texas MD Anderson Cancer Center)

  • Prahlad T. Ram

    (The University of Texas MD Anderson Cancer Center)

  • Murali K. Ravoori

    (The University of Texas MD Anderson Cancer Center)

  • Vikas Kundra

    (The University of Texas MD Anderson Cancer Center)

  • Xinna Zhang

    (Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Rouba Ali-Fehmi

    (Wayne State University School of Medicine, Karmanos Cancer Institute)

  • Ana-Maria Gonzalez-Angulo

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Pierre P. Massion

    (Pulmonary and Critical Care Medicine, Thoracic Program, Vanderbilt Ingram Cancer Center and Veterans Affairs)

  • George A. Calin

    (Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Gabriel Lopez-Berestein

    (Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Wei Zhang

    (The University of Texas MD Anderson Cancer Center
    Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center)

  • Anil K. Sood

    (The University of Texas MD Anderson Cancer Center
    Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

Abstract

The miR-200 family is well known to inhibit the epithelial–mesenchymal transition, suggesting it may therapeutically inhibit metastatic biology. However, conflicting reports regarding the role of miR-200 in suppressing or promoting metastasis in different cancer types have left unanswered questions. Here we demonstrate a difference in clinical outcome based on miR-200’s role in blocking tumour angiogenesis. We demonstrate that miR-200 inhibits angiogenesis through direct and indirect mechanisms by targeting interleukin-8 and CXCL1 secreted by the tumour endothelial and cancer cells. Using several experimental models, we demonstrate the therapeutic potential of miR-200 delivery in ovarian, lung, renal and basal-like breast cancers by inhibiting angiogenesis. Delivery of miR-200 members into the tumour endothelium resulted in marked reductions in metastasis and angiogenesis, and induced vascular normalization. The role of miR-200 in blocking cancer angiogenesis in a cancer-dependent context defines its utility as a potential therapeutic agent.

Suggested Citation

  • Chad V. Pecot & Rajesha Rupaimoole & Da Yang & Rehan Akbani & Cristina Ivan & Chunhua Lu & Sherry Wu & Hee-Dong Han & Maitri Y. Shah & Cristian Rodriguez-Aguayo & Justin Bottsford-Miller & Yuexin Liu , 2013. "Tumour angiogenesis regulation by the miR-200 family," Nature Communications, Nature, vol. 4(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3427
    DOI: 10.1038/ncomms3427
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