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Control of synaptic vesicle endocytosis by an extracellular signalling molecule

Author

Listed:
  • Karen J. Smillie

    (Centre for Integrative Physiology, George Square, University of Edinburgh)

  • Jonathan Pawson

    (Centre for Integrative Physiology, George Square, University of Edinburgh)

  • Emma M. Perkins

    (Centre for Integrative Physiology, George Square, University of Edinburgh)

  • Mandy Jackson

    (Centre for Integrative Physiology, George Square, University of Edinburgh)

  • Michael A. Cousin

    (Centre for Integrative Physiology, George Square, University of Edinburgh)

Abstract

Signalling cascades control multiple aspects of presynaptic function. Synaptic vesicle endocytosis was assumed to be exempt from modulation, due to its essential role maintaining synaptic vesicle supply and thus neurotransmission. Here we show that brain-derived neurotrophic factor arrests the rephosphorylation of the endocytosis enzyme dynamin I via an inhibition of glycogen synthase kinase 3. This event results in a selective inhibition of activity-dependent bulk endocytosis during high-intensity firing. Furthermore, the continued presence of brain-derived neurotrophic factor alleviates the rundown of neurotransmission during high activity. Thus, synaptic strength can be modulated by extracellular signalling molecules via a direct inhibition of a synaptic vesicle endocytosis mode.

Suggested Citation

  • Karen J. Smillie & Jonathan Pawson & Emma M. Perkins & Mandy Jackson & Michael A. Cousin, 2013. "Control of synaptic vesicle endocytosis by an extracellular signalling molecule," Nature Communications, Nature, vol. 4(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3394
    DOI: 10.1038/ncomms3394
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