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Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type

Author

Listed:
  • Gregor-Alexander Pilz

    (Institute of Stem Cell Research, Helmholtz Center Munich)

  • Atsunori Shitamukai

    (RIKEN Center for Developmental Biology)

  • Isabel Reillo

    (Developmental Neurobiology Unit, Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas—Universidad Miguel Hernández)

  • Emilie Pacary

    (MRC National Institute for Medical Research
    Present address: Institut National de la Santé et de la Recherche Médicale, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862, F-33000 Bordeaux, France; Université de Bordeaux, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862, F-33000 Bordeaux, France)

  • Julia Schwausch

    (Institute of Stem Cell Research, Helmholtz Center Munich)

  • Ronny Stahl

    (Physiological Genomics, University of Munich)

  • Jovica Ninkovic

    (Institute of Stem Cell Research, Helmholtz Center Munich)

  • Hugo J. Snippert

    (Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Center Utrecht)

  • Hans Clevers

    (Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Center Utrecht)

  • Leanne Godinho

    (Institute of Stem Cell Research, Helmholtz Center Munich
    Present address: Biomolecular Sensors, Institute of Neuroscience, Technische Universität München, 80802 Munich, Germany)

  • Francois Guillemot

    (MRC National Institute for Medical Research)

  • Victor Borrell

    (Developmental Neurobiology Unit, Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas—Universidad Miguel Hernández)

  • Fumio Matsuzaki

    (RIKEN Center for Developmental Biology)

  • Magdalena Götz

    (Institute of Stem Cell Research, Helmholtz Center Munich
    Physiological Genomics, University of Munich
    Munich Cluster for Systems Neurology (SyNergy))

Abstract

The mechanisms governing the expansion of neuron number in specific brain regions are still poorly understood. Enlarged neuron numbers in different species are often anticipated by increased numbers of progenitors dividing in the subventricular zone. Here we present live imaging analysis of radial glial cells and their progeny in the ventral telencephalon, the region with the largest subventricular zone in the murine brain during neurogenesis. We observe lineage amplification by a new type of progenitor, including bipolar radial glial cells dividing at subapical positions and generating further proliferating progeny. The frequency of this new type of progenitor is increased not only in larger clones of the mouse lateral ganglionic eminence but also in cerebral cortices of gyrated species, and upon inducing gyrification in the murine cerebral cortex. This implies key roles of this new type of radial glia in ontogeny and phylogeny.

Suggested Citation

  • Gregor-Alexander Pilz & Atsunori Shitamukai & Isabel Reillo & Emilie Pacary & Julia Schwausch & Ronny Stahl & Jovica Ninkovic & Hugo J. Snippert & Hans Clevers & Leanne Godinho & Francois Guillemot & , 2013. "Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type," Nature Communications, Nature, vol. 4(1), pages 1-11, October.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3125
    DOI: 10.1038/ncomms3125
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