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Integrating DNA strand-displacement circuitry with DNA tile self-assembly

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  • David Yu Zhang

    (California Institute of Technology
    Present address: Department of Bioengineering, Rice University, Houston, Texas, USA)

  • Rizal F. Hariadi

    (California Institute of Technology
    Present address: Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA)

  • Harry M.T. Choi

    (California Institute of Technology)

  • Erik Winfree

    (California Institute of Technology
    California Institute of Technology
    California Institute of Technology)

Abstract

DNA nanotechnology has emerged as a reliable and programmable way of controlling matter at the nanoscale through the specificity of Watson–Crick base pairing, allowing both complex self-assembled structures with nanometer precision and complex reaction networks implementing digital and analog behaviors. Here we show how two well-developed frameworks, DNA tile self-assembly and DNA strand-displacement circuits, can be systematically integrated to provide programmable kinetic control of self-assembly. We demonstrate the triggered and catalytic isothermal self-assembly of DNA nanotubes over 10 μm long from precursor DNA double-crossover tiles activated by an upstream DNA catalyst network. Integrating more sophisticated control circuits and tile systems could enable precise spatial and temporal organization of dynamic molecular structures.

Suggested Citation

  • David Yu Zhang & Rizal F. Hariadi & Harry M.T. Choi & Erik Winfree, 2013. "Integrating DNA strand-displacement circuitry with DNA tile self-assembly," Nature Communications, Nature, vol. 4(1), pages 1-10, October.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2965
    DOI: 10.1038/ncomms2965
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