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Involvement of the Wnt/β-catenin pathway in neurectoderm architecture in Platynereis dumerilii

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  • Adrien Demilly

    (Institut Jacques Monod, CNRS, UMR 7592, Univ Paris Diderot, Sorbonne Paris Cité)

  • Patrick Steinmetz

    (Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Center of Organismal Systems Biology, Faculty of Life Sciences, University of Vienna)

  • Eve Gazave

    (Institut Jacques Monod, CNRS, UMR 7592, Univ Paris Diderot, Sorbonne Paris Cité)

  • Lauriane Marchand

    (Institut Jacques Monod, CNRS, UMR 7592, Univ Paris Diderot, Sorbonne Paris Cité)

  • Michel Vervoort

    (Institut Jacques Monod, CNRS, UMR 7592, Univ Paris Diderot, Sorbonne Paris Cité
    Institut Universitaire de France, 103, bd Saint-Michel, 75005 Paris, France)

Abstract

Signalling pathways are essential for the correct development of the central nervous system (CNS) in bilaterian animals. Here we show that in the CNS of the annelid Platynereis dumerilii, neural progenitor cells (NPCs) are located close to the ventral midline and express axin, a negative regulator of the Wnt/β-catenin pathway. Using pharmacological inhibitors, we observe that Wnt/β-catenin is required for the transition between proliferating NPCs and differentiating neurons. We also show that the Rho-associated kinase (Rok) is necessary for neurectoderm morphogenesis and ventral midline formation, and indirectly affects the distribution of the NPCs and the development of axonal scaffolds. Moreover, seven genes belonging to the planar cell polarity (PCP) pathway are expressed in the developing Platynereis neurectoderm, suggesting an involvement in its morphogenesis. When compared with previous studies in vertebrates, our data suggest that the involvement of the Wnt/β-catenin pathway in the control of neural cell proliferation/differentiation is ancestral to bilaterians.

Suggested Citation

  • Adrien Demilly & Patrick Steinmetz & Eve Gazave & Lauriane Marchand & Michel Vervoort, 2013. "Involvement of the Wnt/β-catenin pathway in neurectoderm architecture in Platynereis dumerilii," Nature Communications, Nature, vol. 4(1), pages 1-11, October.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2915
    DOI: 10.1038/ncomms2915
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