Author
Listed:
- Costis Papanayotou
(University College London
Present address: Équipe ‘Specification des destins cellulaires chez la souris’, Institut Jacques Monod, CNRS-Université Paris Diderot, 15 rue Hélène Brion, 75205 Paris, France)
- Irene De Almeida
(University College London)
- Ping Liao
(Yong Loo Lin School of Medicine, National University of Singapore
National Neuroscience Institute, Jalan Tan Tock Seng)
- Nidia M. M. Oliveira
(University College London)
- Song-Qing Lu
(National Neuroscience Institute, Jalan Tan Tock Seng)
- Eleni Kougioumtzidou
(University College London)
- Lei Zhu
(Present address: Crystal BioScience, 1450 Rollins Road, Burlingame, California 94010, USA)
- Alex Shaw
(University College London)
- Guojun Sheng
(University College London
Present address: Lab for Early Embryogenesis, Riken Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-Ku, Kobe 650-0047, Japan)
- Andrea Streit
(King’s College London)
- Dejie Yu
(Yong Loo Lin School of Medicine, National University of Singapore)
- Tuck Wah Soong
(Yong Loo Lin School of Medicine, National University of Singapore
National Neuroscience Institute, Jalan Tan Tock Seng)
- Claudio D. Stern
(University College London)
Abstract
Calcium fluxes have been implicated in the specification of the vertebrate embryonic nervous system for some time, but how these fluxes are regulated and how they relate to the rest of the neural induction cascade is unknown. Here we describe Calfacilitin, a transmembrane calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CaV1.2 channel. Calfacilitin binds to this channel and is co-expressed with it in the embryo. Regulation of intracellular calcium by Calfacilitin is required for expression of the neural plate specifiers Geminin and Sox2 and for neural plate formation. Loss-of-function of Calfacilitin can be rescued by ionomycin, which increases intracellular calcium. Our results elucidate the role of calcium fluxes in early neural development and uncover a new factor in the modulation of calcium signalling.
Suggested Citation
Costis Papanayotou & Irene De Almeida & Ping Liao & Nidia M. M. Oliveira & Song-Qing Lu & Eleni Kougioumtzidou & Lei Zhu & Alex Shaw & Guojun Sheng & Andrea Streit & Dejie Yu & Tuck Wah Soong & Claudi, 2013.
"Calfacilitin is a calcium channel modulator essential for initiation of neural plate development,"
Nature Communications, Nature, vol. 4(1), pages 1-11, October.
Handle:
RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2864
DOI: 10.1038/ncomms2864
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