IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms2864.html
   My bibliography  Save this article

Calfacilitin is a calcium channel modulator essential for initiation of neural plate development

Author

Listed:
  • Costis Papanayotou

    (University College London
    Present address: Équipe ‘Specification des destins cellulaires chez la souris’, Institut Jacques Monod, CNRS-Université Paris Diderot, 15 rue Hélène Brion, 75205 Paris, France)

  • Irene De Almeida

    (University College London)

  • Ping Liao

    (Yong Loo Lin School of Medicine, National University of Singapore
    National Neuroscience Institute, Jalan Tan Tock Seng)

  • Nidia M. M. Oliveira

    (University College London)

  • Song-Qing Lu

    (National Neuroscience Institute, Jalan Tan Tock Seng)

  • Eleni Kougioumtzidou

    (University College London)

  • Lei Zhu

    (Present address: Crystal BioScience, 1450 Rollins Road, Burlingame, California 94010, USA)

  • Alex Shaw

    (University College London)

  • Guojun Sheng

    (University College London
    Present address: Lab for Early Embryogenesis, Riken Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-Ku, Kobe 650-0047, Japan)

  • Andrea Streit

    (King’s College London)

  • Dejie Yu

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Tuck Wah Soong

    (Yong Loo Lin School of Medicine, National University of Singapore
    National Neuroscience Institute, Jalan Tan Tock Seng)

  • Claudio D. Stern

    (University College London)

Abstract

Calcium fluxes have been implicated in the specification of the vertebrate embryonic nervous system for some time, but how these fluxes are regulated and how they relate to the rest of the neural induction cascade is unknown. Here we describe Calfacilitin, a transmembrane calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CaV1.2 channel. Calfacilitin binds to this channel and is co-expressed with it in the embryo. Regulation of intracellular calcium by Calfacilitin is required for expression of the neural plate specifiers Geminin and Sox2 and for neural plate formation. Loss-of-function of Calfacilitin can be rescued by ionomycin, which increases intracellular calcium. Our results elucidate the role of calcium fluxes in early neural development and uncover a new factor in the modulation of calcium signalling.

Suggested Citation

  • Costis Papanayotou & Irene De Almeida & Ping Liao & Nidia M. M. Oliveira & Song-Qing Lu & Eleni Kougioumtzidou & Lei Zhu & Alex Shaw & Guojun Sheng & Andrea Streit & Dejie Yu & Tuck Wah Soong & Claudi, 2013. "Calfacilitin is a calcium channel modulator essential for initiation of neural plate development," Nature Communications, Nature, vol. 4(1), pages 1-11, October.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2864
    DOI: 10.1038/ncomms2864
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms2864
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms2864?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2864. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.