IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms2721.html
   My bibliography  Save this article

Arginine clustering on calix[4]arene macrocycles for improved cell penetration and DNA delivery

Author

Listed:
  • Valentina Bagnacani

    (Università degli Studi di Parma, Parco Area delle Scienze 17/a)

  • Valentina Franceschi

    (Università degli Studi di Parma, Via del Taglio 6)

  • Michele Bassi

    (Università degli Studi di Parma, Parco Area delle Scienze 17/a)

  • Michela Lomazzi

    (Università degli Studi di Parma, Parco Area delle Scienze 17/a)

  • Gaetano Donofrio

    (Università degli Studi di Parma, Via del Taglio 6)

  • Francesco Sansone

    (Università degli Studi di Parma, Parco Area delle Scienze 17/a)

  • Alessandro Casnati

    (Università degli Studi di Parma, Parco Area delle Scienze 17/a)

  • Rocco Ungaro

    (Università degli Studi di Parma, Parco Area delle Scienze 17/a)

Abstract

Cell-penetrating peptides are widely used as molecular transporters for the internalization inside cells of various cargo, including proteins and nucleic acids. A special role is played by arginine-rich peptides and oligoarginines covalently linked or simply mixed with the cargo. Here we report cell-penetrating agents in which arginine units are clustered on a macrocyclic scaffold. Instead of using long peptides, four single arginine units were covalently attached to either the upper or lower rim of a calix[4]arene, kept in the cone conformation building a ‘parallel’ cyclic array. These new macrocyclic carriers show high efficiency in DNA delivery and transfection in a variety of cell lines.

Suggested Citation

  • Valentina Bagnacani & Valentina Franceschi & Michele Bassi & Michela Lomazzi & Gaetano Donofrio & Francesco Sansone & Alessandro Casnati & Rocco Ungaro, 2013. "Arginine clustering on calix[4]arene macrocycles for improved cell penetration and DNA delivery," Nature Communications, Nature, vol. 4(1), pages 1-7, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2721
    DOI: 10.1038/ncomms2721
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms2721
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms2721?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2721. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.