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Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice

Author

Listed:
  • Jun Kunisawa

    (The Institute of Medical Science, The University of Tokyo
    Graduate School of Frontier Science, The University of Tokyo
    International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo
    Laboratory of Vaccine Materials, National Institute of Biomedical Innovation)

  • Masashi Gohda

    (The Institute of Medical Science, The University of Tokyo
    Graduate School of Frontier Science, The University of Tokyo)

  • Eri Hashimoto

    (The Institute of Medical Science, The University of Tokyo)

  • Izumi Ishikawa

    (The Institute of Medical Science, The University of Tokyo)

  • Morio Higuchi

    (The Institute of Medical Science, The University of Tokyo
    Graduate School of Medicine, The University of Tokyo)

  • Yuji Suzuki

    (The Institute of Medical Science, The University of Tokyo)

  • Yoshiyuki Goto

    (The Institute of Medical Science, The University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
    Columbia University Medical Center)

  • Casandra Panea

    (Columbia University Medical Center)

  • Ivaylo I. Ivanov

    (Columbia University Medical Center)

  • Risa Sumiya

    (The Institute of Medical Science, The University of Tokyo)

  • Lamichhane Aayam

    (The Institute of Medical Science, The University of Tokyo
    Graduate School of Frontier Science, The University of Tokyo)

  • Taichi Wake

    (The Institute of Medical Science, The University of Tokyo
    Graduate School of Medicine, The University of Tokyo)

  • So Tajiri

    (The Institute of Medical Science, The University of Tokyo
    Graduate School of Frontier Science, The University of Tokyo)

  • Yosuke Kurashima

    (The Institute of Medical Science, The University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
    Graduate School of Medicine, The University of Tokyo)

  • Shiori Shikata

    (The Institute of Medical Science, The University of Tokyo)

  • Shizuo Akira

    (Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University)

  • Kiyoshi Takeda

    (Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
    Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University)

  • Hiroshi Kiyono

    (The Institute of Medical Science, The University of Tokyo
    Graduate School of Frontier Science, The University of Tokyo
    International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency)

Abstract

Intestinal plasma cells predominantly produce immunoglobulin (Ig) A, however, their functional diversity remains poorly characterized. Here we show that murine intestinal IgA plasma cells can be newly classified into two populations on the basis of CD11b expression, which cannot be discriminated by currently known criteria such as general plasma cell markers, B cell origin and T cell dependence. CD11b+ IgA+ plasma cells require the lymphoid structure of Peyer’s patches, produce more IgA than CD11b− IgA+ plasma cells, proliferate vigorously, and require microbial stimulation and IL-10 for their development and maintenance. These features allow CD11b+ IgA+ plasma cells to mediate early-phase antigen-specific intestinal IgA responses induced by oral immunization with protein antigen. These findings reveal the functional diversity of IgA+ plasma cells in the murine intestine.

Suggested Citation

  • Jun Kunisawa & Masashi Gohda & Eri Hashimoto & Izumi Ishikawa & Morio Higuchi & Yuji Suzuki & Yoshiyuki Goto & Casandra Panea & Ivaylo I. Ivanov & Risa Sumiya & Lamichhane Aayam & Taichi Wake & So Taj, 2013. "Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice," Nature Communications, Nature, vol. 4(1), pages 1-10, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2718
    DOI: 10.1038/ncomms2718
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