IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms2627.html
   My bibliography  Save this article

Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells

Author

Listed:
  • Euan S. Polson

    (YCR Cancer Research Unit, University of York)

  • John L. Lewis

    (YCR Cancer Research Unit, University of York)

  • Hamza Celik

    (Laboratoire de Chimie Bactérienne, UMR7283-CNRS, Aix-Marseille Université)

  • Vincent M. Mann

    (Hull York Medical School, University of Hull)

  • Michael J. Stower

    (York District Hospital)

  • Matthew S. Simms

    (Hull York Medical School, University of Hull
    Castle Hill Hospital)

  • Greta Rodrigues

    (Hull Royal Infirmary)

  • Anne T. Collins

    (YCR Cancer Research Unit, University of York)

  • Norman J. Maitland

    (YCR Cancer Research Unit, University of York)

Abstract

While chromosomal translocations have a fundamental role in the development of several human leukaemias, their role in solid tumour development has been somewhat more controversial. Recently, it was shown that up to 80% of prostate tumours harbour at least one such gene fusion, and that the most common fusion event, between the prostate-specific TMPRSS2 gene and the ERG oncogene, is a critical, and probably early factor in prostate cancer development. Here we demonstrate the presence and expression of this significant chromosomal rearrangement in prostate cancer stem cells. Moreover, we show that in the prostate epithelial hierarchy from both normal and tumour tissues, TMPRSS2 transcription is subjected to tight monoallelic regulation, which is retained upon asymmetric division and relaxed during epithelial cell differentiation. The presence and expression of TMPRSS2/ERG in prostate stem cells would provide ERG-driven survival advantages, allowing maintenance of this mutated genotype.

Suggested Citation

  • Euan S. Polson & John L. Lewis & Hamza Celik & Vincent M. Mann & Michael J. Stower & Matthew S. Simms & Greta Rodrigues & Anne T. Collins & Norman J. Maitland, 2013. "Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells," Nature Communications, Nature, vol. 4(1), pages 1-9, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2627
    DOI: 10.1038/ncomms2627
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms2627
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms2627?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2627. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.