IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms2625.html
   My bibliography  Save this article

A chronic model of arthritis supported by a strain-specific periarticular lymph node in BALB/c mice

Author

Listed:
  • Uta Baddack

    (Max-Delbrück-Center of Molecular Medicine (MDC))

  • Sven Hartmann

    (Max-Delbrück-Center of Molecular Medicine (MDC))

  • Holger Bang

    (ORGENTEC Diagnostika GmbH)

  • Jenny Grobe

    (Max-Delbrück-Center of Molecular Medicine (MDC))

  • Christoph Loddenkemper

    (Charité Medical University, Campus Benjamin Franklin)

  • Martin Lipp

    (Max-Delbrück-Center of Molecular Medicine (MDC))

  • Gerd Müller

    (Max-Delbrück-Center of Molecular Medicine (MDC))

Abstract

Current animal models of arthritis only partially reflect the complexity of rheumatoid arthritis and typically lack either chronicity or autoantibody formation. Here we describe a model that combines features of antigen-induced arthritis and collagen-induced arthritis, which can be efficiently induced in BALB/c and C57BL/6 mice. However, BALB/c mice generate significantly higher titres of anticollagen and anticitrullinated peptide antibodies, show a stronger progressive joint destruction, and in the chronic phase the disease spreads between joints. Concomitant to the observation of a more severe pathology, we discovered a previously undescribed small periarticular lymph node in close proximity to the knee joint of BALB/c mice, which acts as the primary draining lymph node for the synovial cavity. Our model more closely reflects the pathology of rheumatoid arthritis than classical models of arthritis and is hence particularly suitable for further studies of disease pathogenesis.

Suggested Citation

  • Uta Baddack & Sven Hartmann & Holger Bang & Jenny Grobe & Christoph Loddenkemper & Martin Lipp & Gerd Müller, 2013. "A chronic model of arthritis supported by a strain-specific periarticular lymph node in BALB/c mice," Nature Communications, Nature, vol. 4(1), pages 1-10, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2625
    DOI: 10.1038/ncomms2625
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms2625
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms2625?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2625. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.