IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms2491.html
   My bibliography  Save this article

Extracellular matrix inhibits structural and functional plasticity of dendritic spines in the adult visual cortex

Author

Listed:
  • L. de Vivo

    (NEST, Istituto Nanoscienze-CNR
    Institute of Neuroscience CNR)

  • S. Landi

    (NEST, Istituto Nanoscienze-CNR
    NEST, Scuola Normale Superiore)

  • M. Panniello

    (NEST, Scuola Normale Superiore
    Center for Nanotechnology Innovation, NEST)

  • L. Baroncelli

    (Institute of Neuroscience CNR)

  • S. Chierzi

    (Institute of Neuroscience CNR)

  • L. Mariotti

    (NEST, Scuola Normale Superiore
    Center for Nanotechnology Innovation, NEST)

  • M. Spolidoro

    (Institute of Neuroscience CNR)

  • T. Pizzorusso

    (Institute of Neuroscience CNR
    Area del Farmaco e Salute del Bambino Università degli Studi di Firenze)

  • L. Maffei

    (Institute of Neuroscience CNR)

  • G.M. Ratto

    (NEST, Istituto Nanoscienze-CNR
    NEST, Scuola Normale Superiore)

Abstract

Brain cells are immersed in a complex structure forming the extracellular matrix. The composition of the matrix gradually matures during postnatal development, as the brain circuitry reaches its adult form. The fully developed extracellular environment stabilizes neuronal connectivity and decreases cortical plasticity as highlighted by the demonstration that treatments degrading the matrix are able to restore synaptic plasticity in the adult brain. The mechanisms through which the matrix inhibits cortical plasticity are not fully clarified. Here we show that a prominent component of the matrix, chondroitin sulfate proteoglycans (CSPGs), restrains morphological changes of dendritic spines in the visual cortex of adult mice. By means of in vivo and in vitro two-photon imaging and electrophysiology, we find that after enzymatic digestion of CSPGs, cortical spines become more motile and express a larger degree of structural and functional plasticity.

Suggested Citation

  • L. de Vivo & S. Landi & M. Panniello & L. Baroncelli & S. Chierzi & L. Mariotti & M. Spolidoro & T. Pizzorusso & L. Maffei & G.M. Ratto, 2013. "Extracellular matrix inhibits structural and functional plasticity of dendritic spines in the adult visual cortex," Nature Communications, Nature, vol. 4(1), pages 1-10, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2491
    DOI: 10.1038/ncomms2491
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms2491
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms2491?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2491. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.