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IGF-1 promotes the development and cytotoxic activity of human NK cells

Author

Listed:
  • Fang Ni

    (Institute of Immunology, School of Life Sciences, University of Science and Technology of China
    Anhui Medical University)

  • Rui Sun

    (Institute of Immunology, School of Life Sciences, University of Science and Technology of China)

  • Binqing Fu

    (Institute of Immunology, School of Life Sciences, University of Science and Technology of China
    Hefei National Laboratory for Physical Sciences at Microscale)

  • Fuyan Wang

    (Institute of Immunology, School of Life Sciences, University of Science and Technology of China)

  • Chuang Guo

    (Institute of Immunology, School of Life Sciences, University of Science and Technology of China)

  • Zhigang Tian

    (Institute of Immunology, School of Life Sciences, University of Science and Technology of China
    Hefei National Laboratory for Physical Sciences at Microscale)

  • Haiming Wei

    (Institute of Immunology, School of Life Sciences, University of Science and Technology of China)

Abstract

Insulin-like growth factor 1 (IGF-1) is a critical regulator of many physiological functions, ranging from longevity to immunity. However, little is known about the role of IGF-1 in natural killer cell development and function. Here, we identify an essential role for IGF-1 in the positive regulation of human natural killer cell development and cytotoxicity. Specifically, we show that human natural killer cells have the ability to produce IGF-1 and that differential endogenous IGF-1 expression leads to disparate cytotoxicity in human primary natural killer cells. Moreover, miR-483-3p is identified as a critical regulator of IGF-1 expression in natural killer cells. Overexpression of miR-483-3p has an effect similar to IGF-1 blockade and decreased natural killer cell cytotoxicity, whereas inhibition of miR-483-3p has the opposite effect, which is reversible with IGF-1 neutralizing antibody. These findings indicate that IGF-1 and miR-483-3p belong to a new class of natural killer cell functional modulators and strengthen the prominent role of IGF-1 in innate immunity.

Suggested Citation

  • Fang Ni & Rui Sun & Binqing Fu & Fuyan Wang & Chuang Guo & Zhigang Tian & Haiming Wei, 2013. "IGF-1 promotes the development and cytotoxic activity of human NK cells," Nature Communications, Nature, vol. 4(1), pages 1-11, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2484
    DOI: 10.1038/ncomms2484
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