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Genome of the Chinese tree shrew

Author

Listed:
  • Yu Fan

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
    University of Chinese Academy of Sciences)

  • Zhi-Yong Huang

    (BGI-Shenzhen)

  • Chang-Chang Cao

    (BGI-Shenzhen)

  • Ce-Shi Chen

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming)

  • Yuan-Xin Chen

    (BGI-Shenzhen)

  • Ding-Ding Fan

    (BGI-Shenzhen)

  • Jing He

    (BGI-Shenzhen)

  • Hao-Long Hou

    (BGI-Shenzhen)

  • Li Hu

    (BGI-Shenzhen)

  • Xin-Tian Hu

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming)

  • Xuan-Ting Jiang

    (BGI-Shenzhen)

  • Ren Lai

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming)

  • Yong-Shan Lang

    (BGI-Shenzhen)

  • Bin Liang

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming)

  • Sheng-Guang Liao

    (BGI-Shenzhen)

  • Dan Mu

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
    University of Chinese Academy of Sciences)

  • Yuan-Ye Ma

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming)

  • Yu-Yu Niu

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming)

  • Xiao-Qing Sun

    (BGI-Shenzhen)

  • Jin-Quan Xia

    (BGI-Shenzhen)

  • Jin Xiao

    (BGI-Shenzhen)

  • Zhi-Qiang Xiong

    (BGI-Shenzhen)

  • Lin Xu

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming)

  • Lan Yang

    (BGI-Shenzhen)

  • Yun Zhang

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming)

  • Wei Zhao

    (BGI-Shenzhen)

  • Xu-Dong Zhao

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming)

  • Yong-Tang Zheng

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming)

  • Ju-Min Zhou

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming)

  • Ya-Bing Zhu

    (BGI-Shenzhen)

  • Guo-Jie Zhang

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
    BGI-Shenzhen
    University of Copenhagen, DK-2200)

  • Jun Wang

    (BGI-Shenzhen
    Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200
    University of Copenhagen, DK-2200
    King Abdulaziz University, 21589 Jeddah)

  • Yong-Gang Yao

    (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming)

Abstract

Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as models for a variety of human disorders: depression, myopia, hepatitis B and C virus infections, and hepatocellular carcinoma, to name a few. Here we present a publicly available annotated genome sequence for the Chinese tree shrew. Phylogenomic analysis of the tree shrew and other mammalians highly support its close affinity to primates. By characterizing key factors and signalling pathways in nervous and immune systems, we demonstrate that tree shrews possess both shared common and unique features, and provide a genetic basis for the use of this animal as a potential model for biomedical research.

Suggested Citation

  • Yu Fan & Zhi-Yong Huang & Chang-Chang Cao & Ce-Shi Chen & Yuan-Xin Chen & Ding-Ding Fan & Jing He & Hao-Long Hou & Li Hu & Xin-Tian Hu & Xuan-Ting Jiang & Ren Lai & Yong-Shan Lang & Bin Liang & Sheng-, 2013. "Genome of the Chinese tree shrew," Nature Communications, Nature, vol. 4(1), pages 1-9, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2416
    DOI: 10.1038/ncomms2416
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