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In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels

Author

Listed:
  • Hidekazu Sekine

    (Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, TWIns)

  • Tatsuya Shimizu

    (Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, TWIns)

  • Katsuhisa Sakaguchi

    (Faculty of Science and Engineering, Waseda University, TWIns)

  • Izumi Dobashi

    (Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, TWIns)

  • Masanori Wada

    (ABLE Corporation)

  • Masayuki Yamato

    (Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, TWIns)

  • Eiji Kobayashi

    (Center for Development of Advanced Medical Technology, Jichi Medical University)

  • Mitsuo Umezu

    (Faculty of Science and Engineering, Waseda University, TWIns)

  • Teruo Okano

    (Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, TWIns)

Abstract

Artificially engineered tissues may have many therapeutic applications but complex tissues are hard to create in vitro. Here, Okano and colleagues report the production of functional cardiac tissue sheets with perfusable blood vessels, which increase the thickness and survival of transplanted tissue.

Suggested Citation

  • Hidekazu Sekine & Tatsuya Shimizu & Katsuhisa Sakaguchi & Izumi Dobashi & Masanori Wada & Masayuki Yamato & Eiji Kobayashi & Mitsuo Umezu & Teruo Okano, 2013. "In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels," Nature Communications, Nature, vol. 4(1), pages 1-10, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2406
    DOI: 10.1038/ncomms2406
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