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Selective escape of proteins from the mitochondria during mitophagy

Author

Listed:
  • Shotaro Saita

    (Medical Institute of Bioregulation, Kyushu University
    CREST, Japan Science and Technology Agency)

  • Michiko Shirane

    (Medical Institute of Bioregulation, Kyushu University
    CREST, Japan Science and Technology Agency)

  • Keiichi I. Nakayama

    (Medical Institute of Bioregulation, Kyushu University
    CREST, Japan Science and Technology Agency)

Abstract

Mitophagy refers to the degradation of mitochondria by the autophagy system that is regulated by Parkin and PINK1, mutations in the genes for which have been linked to Parkinson’s disease. Here we show that certain mitochondrial outer membrane proteins, including FKBP38 and Bcl-2, translocate from the mitochondria to the endoplasmic reticulum (ER) during mitophagy, thereby escaping degradation by autophagosomes. This translocation depends on the ubiquitylation activity of Parkin and on microtubule polymerization. Photoconversion analysis confirmed that FKBP38 detected at the ER during mitophagy indeed represents preexisting protein transported from the mitochondria. The escape of FKBP38 and Bcl-2 from the mitochondria is determined by the number of basic amino acids in their COOH-terminal signal sequences. Furthermore, the translocation of FKBP38 is essential for the suppression of apoptosis during mitophagy. Our results thus show that not all mitochondrial proteins are degraded during mitophagy, with some proteins being evacuated to the ER to prevent unwanted apoptosis.

Suggested Citation

  • Shotaro Saita & Michiko Shirane & Keiichi I. Nakayama, 2013. "Selective escape of proteins from the mitochondria during mitophagy," Nature Communications, Nature, vol. 4(1), pages 1-14, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2400
    DOI: 10.1038/ncomms2400
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    Cited by:

    1. Koki Nakamura & Saeko Aoyama-Ishiwatari & Takahiro Nagao & Mohammadreza Paaran & Christopher J. Obara & Yui Sakurai-Saito & Jake Johnston & Yudan Du & Shogo Suga & Masafumi Tsuboi & Makoto Nakakido & , 2025. "Mitochondrial complexity is regulated at ER-mitochondria contact sites via PDZD8-FKBP8 tethering," Nature Communications, Nature, vol. 16(1), pages 1-23, December.

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