IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms2393.html
   My bibliography  Save this article

MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11

Author

Listed:
  • Jessica Bockhorn

    (The University of Chicago
    The University of Chicago)

  • Rachel Dalton

    (The University of Chicago)

  • Chika Nwachukwu

    (Center for Clinical Cancer Genetics, The University of Chicago
    The University of Chicago)

  • Simo Huang

    (The University of Chicago)

  • Aleix Prat

    (Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
    Present address: Translational Genomics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona 08035, Spain)

  • Kathy Yee

    (The University of Chicago)

  • Ya-Fang Chang

    (The University of Chicago)

  • Dezheng Huo

    (University of Chicago)

  • Yujia Wen

    (The University of Chicago
    Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago)

  • Kaitlin E. Swanson

    (The University of Chicago)

  • Tyler Qiu

    (The University of Chicago)

  • Jun Lu

    (Yale Stem Cell Center and Yale Cancer Center, Yale University)

  • Seo Young Park

    (University of Chicago)

  • M. Eileen Dolan

    (The University of Chicago
    Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago)

  • Charles M. Perou

    (Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill)

  • Olufunmilayo I. Olopade

    (Center for Clinical Cancer Genetics, The University of Chicago
    The University of Chicago)

  • Michael F. Clarke

    (The Institute for Stem Cell Biology and Regenerative Medicine, Stanford University)

  • Geoffrey L. Greene

    (The University of Chicago)

  • Huiping Liu

    (The University of Chicago
    The Institute for Stem Cell Biology and Regenerative Medicine, Stanford University)

Abstract

Chemotherapy resistance frequently drives tumour progression. However, the underlying molecular mechanisms are poorly characterized. Epithelial-to-mesenchymal transition has been shown to correlate with therapy resistance, but the functional link and signalling pathways remain to be elucidated. Here we report that microRNA-30c, a human breast tumour prognostic marker, has a pivotal role in chemoresistance by a direct targeting of the actin-binding protein twinfilin 1, which promotes epithelial-to-mesenchymal transition. An interleukin-6 family member, interleukin-11 is identified as a secondary target of twinfilin 1 in the microRNA-30c signalling pathway. Expression of microRNA-30c inversely correlates with interleukin-11 expression in primary breast tumours and low interleukin-11 correlates with relapse-free survival in breast cancer patients. Our study demonstrates that microRNA-30c is transcriptionally regulated by GATA3 in breast tumours. Identification of a novel microRNA-mediated pathway that regulates chemoresistance in breast cancer will facilitate the development of novel therapeutic strategies.

Suggested Citation

  • Jessica Bockhorn & Rachel Dalton & Chika Nwachukwu & Simo Huang & Aleix Prat & Kathy Yee & Ya-Fang Chang & Dezheng Huo & Yujia Wen & Kaitlin E. Swanson & Tyler Qiu & Jun Lu & Seo Young Park & M. Eilee, 2013. "MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11," Nature Communications, Nature, vol. 4(1), pages 1-14, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2393
    DOI: 10.1038/ncomms2393
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms2393
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms2393?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2393. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.