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Extensive diversification of IgH subclass-encoding genes and IgM subclass switching in crocodilians

Author

Listed:
  • Gang Cheng

    (State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University)

  • Yang Gao

    (State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University)

  • Tao Wang

    (State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University)

  • Yi Sun

    (State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University)

  • Zhiguo Wei

    (College of Animal Science and Technology, Henan University of Science and Technology)

  • Lingxiao Li

    (State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University)

  • Liming Ren

    (State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University)

  • Ying Guo

    (State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University)

  • Xiaoxiang Hu

    (State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University)

  • Yan Lu
  • Xumin Wang

    (Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences)

  • Guiming Liu

    (Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences)

  • Chenglin Zhang
  • Jun Yu

    (Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences)

  • Qiang Pan-Hammarström

    (Karolinska University Hospital Huddinge)

  • Lennart Hammarström

    (Karolinska University Hospital Huddinge)

  • Xiaobing Wu

    (College of Life Sciences, Anhui Normal University, Anhui Provincial Key Laboratory of the Conservation and Exploitation of Biological Resources)

  • Ning Li

    (State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University)

  • Yaofeng Zhao

    (State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University
    Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University)

Abstract

Crocodilians are a group of reptiles that are closely related to birds and are thought to possess a strong immune system. Here we report that the IgH locus in the Siamese crocodile and the Chinese alligator contains multiple μ genes, in contrast to other tetrapods. Both the μ2 and μ3 genes are expressed through class-switch recombination involving the switch region and germline transcription. Both IgM1 and IgM2 are present in the serum as polymers, which implies that IgM class switching may have significant roles in humoural immunity. The crocodilian α genes are the first IgA-encoding genes identified in reptiles, and these genes show an inverted transcriptional orientation similar to that of birds. The identification of both α and δ genes in crocodilians suggests that the IgH loci of modern living mammals, reptiles and birds share a common ancestral organization.

Suggested Citation

  • Gang Cheng & Yang Gao & Tao Wang & Yi Sun & Zhiguo Wei & Lingxiao Li & Liming Ren & Ying Guo & Xiaoxiang Hu & Yan Lu & Xumin Wang & Guiming Liu & Chenglin Zhang & Jun Yu & Qiang Pan-Hammarström & Lenn, 2013. "Extensive diversification of IgH subclass-encoding genes and IgM subclass switching in crocodilians," Nature Communications, Nature, vol. 4(1), pages 1-10, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2317
    DOI: 10.1038/ncomms2317
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