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Activity of the mitochondrial calcium uniporter varies greatly between tissues

Author

Listed:
  • Francesca Fieni

    (University of California, San Francisco, UCSF Mail Code 2140, Genentech Hall Room N272F)

  • Sung Bae Lee

    (University of California, San Francisco, UCSF Mail Code 2140, Genentech Hall Room N272F
    Howard Hughes Medical Institute, University of California, San Francisco, Room 484E
    Present address: Department of Brain Science, Daegu Gyeongbuk Institute of Science and Technology, Daegu 711-873, Korea)

  • Yuh Nung Jan

    (University of California, San Francisco, UCSF Mail Code 2140, Genentech Hall Room N272F
    Howard Hughes Medical Institute, University of California, San Francisco, Room 484E)

  • Yuriy Kirichok

    (University of California, San Francisco, UCSF Mail Code 2140, Genentech Hall Room N272F)

Abstract

The mitochondrial calcium uniporter is a highly selective channel responsible for mitochondrial Ca2+ uptake. The mitochondrial calcium uniporter shapes cytosolic Ca2+ signals, controls mitochondrial ATP production, and is involved in cell death. Here using direct patch-clamp recording from the inner mitochondrial membrane, we compare mitochondrial calcium uniporter activity in mouse heart, skeletal muscle, liver, kidney and brown fat. Surprisingly, heart mitochondria show a dramatically lower mitochondrial calcium uniporter current density than the other tissues studied. Similarly, in Drosophila flight muscle, mitochondrial calcium uniporter activity is barely detectable compared with that in other fly tissues. As mitochondria occupy up to 40% of the cell volume in highly metabolically active heart and flight muscle, low mitochondrial calcium uniporter activity is likely essential to avoid cytosolic Ca2+ sink due to excessive mitochondrial Ca2+ uptake. Simultaneously, low mitochondrial calcium uniporter activity may also prevent mitochondrial Ca2+ overload in such active tissues exposed to frequent cytosolic Ca2+ activity.

Suggested Citation

  • Francesca Fieni & Sung Bae Lee & Yuh Nung Jan & Yuriy Kirichok, 2012. "Activity of the mitochondrial calcium uniporter varies greatly between tissues," Nature Communications, Nature, vol. 3(1), pages 1-12, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms2325
    DOI: 10.1038/ncomms2325
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    Cited by:

    1. Enrique Balderas & David R. Eberhardt & Sandra Lee & John M. Pleinis & Salah Sommakia & Anthony M. Balynas & Xue Yin & Mitchell C. Parker & Colin T. Maguire & Scott Cho & Marta W. Szulik & Anna Bakhti, 2022. "Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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