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Pioneer glutamatergic cells develop into a morpho-functionally distinct population in the juvenile CA3 hippocampus

Author

Listed:
  • Thomas Marissal

    (Inserm Unité 901
    Université de la Méditerranée, UMR S901 Aix-Marseille 2
    INMED)

  • Paolo Bonifazi

    (School of Physics and Astronomy, Tel Aviv University)

  • Michel Aimé Picardo

    (Inserm Unité 901
    Université de la Méditerranée, UMR S901 Aix-Marseille 2
    INMED)

  • Romain Nardou

    (Inserm Unité 901
    Université de la Méditerranée, UMR S901 Aix-Marseille 2
    INMED)

  • Ludovic Franck Petit

    (Inserm Unité 901
    Université de la Méditerranée, UMR S901 Aix-Marseille 2
    INMED)

  • Agnès Baude

    (Inserm Unité 901
    Université de la Méditerranée, UMR S901 Aix-Marseille 2
    INMED)

  • Gordon James Fishell

    (and Neural Science, and Langone Medical Center, New York University Neuroscience Institute)

  • Yehezkel Ben-Ari

    (Inserm Unité 901
    Université de la Méditerranée, UMR S901 Aix-Marseille 2
    INMED)

  • Rosa Cossart

    (Inserm Unité 901
    Université de la Méditerranée, UMR S901 Aix-Marseille 2
    INMED)

Abstract

The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early postnatal stages is minimal. However, without fast GABAergic transmission, a different situation may prevail. In the adult CA3, blocking fast GABAergic transmission induces the generation of network bursts that can be triggered by the stimulation of single pyramidal neurons. Here we revisit the network function of CA3 glutamatergic neurons from a developmental viewpoint, without fast GABAergic transmission. We uncover a sub-population of early-generated glutamatergic neurons that impacts network dynamics when stimulated in the juvenile hippocampus. Additionally, this population displays characteristic morpho-physiological features in the juvenile and adult hippocampus. Therefore, the apparently homogeneous glutamatergic cell population likely displays a morpho-functional diversity rooted in temporal embryonic origins.

Suggested Citation

  • Thomas Marissal & Paolo Bonifazi & Michel Aimé Picardo & Romain Nardou & Ludovic Franck Petit & Agnès Baude & Gordon James Fishell & Yehezkel Ben-Ari & Rosa Cossart, 2012. "Pioneer glutamatergic cells develop into a morpho-functionally distinct population in the juvenile CA3 hippocampus," Nature Communications, Nature, vol. 3(1), pages 1-12, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms2318
    DOI: 10.1038/ncomms2318
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