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Elevated oncofoetal miR-17-5p expression regulates colorectal cancer progression by repressing its target gene P130

Author

Listed:
  • Yanlei Ma

    (the Tenth People’s Hospital affiliated to Tongji University, 301 Yanchang Road)

  • Peng Zhang

    (the Tenth People’s Hospital affiliated to Tongji University, 301 Yanchang Road)

  • Feng Wang

    (the Tenth People’s Hospital affiliated to Tongji University, 301 Yanchang Road)

  • Huizhen Zhang

    (the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University)

  • Yongzhi Yang

    (the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University)

  • Chenzhang Shi

    (the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University)

  • Yang Xia

    (the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University)

  • Jiayuan Peng

    (the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University)

  • Weijie Liu

    (the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University)

  • Zhe Yang

    (the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University)

  • Huanlong Qin

    (the Tenth People’s Hospital affiliated to Tongji University, 301 Yanchang Road)

Abstract

MicroRNAs (miRNAs) are essential for regulating normal embryonic development and carcinogenesis. Here we report that miR-17-5p, an oncofoetal miRNA, is a key regulator of colorectal cancer progression. We show that miR-17-5p is an oncogenic miRNA that regulates tumorigenesis and progression by targeting the gene encoding P130 and subsequently activating the Wnt/β-catenin pathway. Using specimens from two large cohorts of colorectal cancer patients, we found that patients whose tumours had high miR-17-5p expression had shorter overall survival rates but showed a better response to adjuvant chemotherapy than did patients whose tumours had low miRNA expression. We also observed a strong inverse correlation between miR-17-5p and P130 expression. The current findings suggest that miR-17-5p is a crucial determinant of colorectal cancer progression.

Suggested Citation

  • Yanlei Ma & Peng Zhang & Feng Wang & Huizhen Zhang & Yongzhi Yang & Chenzhang Shi & Yang Xia & Jiayuan Peng & Weijie Liu & Zhe Yang & Huanlong Qin, 2012. "Elevated oncofoetal miR-17-5p expression regulates colorectal cancer progression by repressing its target gene P130," Nature Communications, Nature, vol. 3(1), pages 1-12, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms2276
    DOI: 10.1038/ncomms2276
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