IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v3y2012i1d10.1038_ncomms2261.html
   My bibliography  Save this article

Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region

Author

Listed:
  • Yosuke Niibori

    (Program in Neurosciences and Mental Health, The Hospital for Sick Children)

  • Tzong-Shiue Yu

    (Program in Neurosciences and Mental Health, The Hospital for Sick Children)

  • Jonathan R. Epp

    (Program in Neurosciences and Mental Health, The Hospital for Sick Children)

  • Katherine G. Akers

    (Program in Neurosciences and Mental Health, The Hospital for Sick Children)

  • Sheena A. Josselyn

    (Program in Neurosciences and Mental Health, The Hospital for Sick Children
    University of Toronto)

  • Paul W. Frankland

    (Program in Neurosciences and Mental Health, The Hospital for Sick Children
    University of Toronto)

Abstract

Different places may share common features, but are coded by distinct populations of CA3 neurons in the hippocampus. Here we show that chemical or genetic suppression of adult neurogenesis in the hippocampus impairs this population-based coding of similar (but not dissimilar) contexts. These data provide a neural basis for impaired spatial discrimination following ablation of adult neurogenesis, and support the proposal that adult neurogenesis regulates the efficiency of a pattern separation process in the hippocampus.

Suggested Citation

  • Yosuke Niibori & Tzong-Shiue Yu & Jonathan R. Epp & Katherine G. Akers & Sheena A. Josselyn & Paul W. Frankland, 2012. "Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region," Nature Communications, Nature, vol. 3(1), pages 1-7, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms2261
    DOI: 10.1038/ncomms2261
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms2261
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms2261?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms2261. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.